From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery systems and personalized medicine

被引：30
|
作者：
Willemen, Niels G. A. [1 ,2 ]
Morsink, Margaretha A. J. [1 ,2 ,3 ]
Veerman, Devin [4 ]
da Silva, Classius F. [5 ]
Cardoso, Juliana C. [6 ,7 ]
Souto, Eliana B. [8 ,9 ]
Severino, Patricia [1 ,6 ,7 ,10 ]
机构：
[1] Harvard Med Sch, Brigham & Women & Hosp, Dept Med, Ctr Biomed Engn, 65 Landsdowne St, Cambridge, MA 02139 USA
[2] Univ Twente, Fac Sci & Technol, Dept Dev BioEngn, Tech Med Ctr, Enschede, Netherlands
[3] Univ Twente, Fac Sci & Technol, Dept Med Cell BioPhys, Tech Med Ctr,Translat Liver Res, Enschede, Netherlands
[4] Univ Twente, Fac Sci & Technol, Dept Biomat Sci & Technol, Targeted Therapeut, Enschede, Netherlands
[5] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Chem Engn, Rua Sao Nicolau 210, BR-09913030 Diadema, Brazil
[6] Univ Tiradentes Unit, Av Murilo Dantas 300, BR-49010390 Aracaju, Brazil
[7] Inst Technol & Res ITP, Av Murilo Dantas 300, BR-49010390 Aracaju, Brazil
[8] Univ Coimbra, Fac Pharm, Polo Ciencias Saude, Azinhaga Santa Comba, P-3000548 Coimbra, Portugal
[9] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
[10] Tiradentes Inst, 150 Mt Vernon St, Dorchester, MA 02125 USA
来源：
BIO-DESIGN AND MANUFACTURING | 2022年 / 5卷 / 01期
关键词：
Drug delivery systems; 3D/4D printing; Drug-eluting implants; Microneedles; Oral formulations; SHAPE-MEMORY POLYURETHANE; BIOLOGICAL-ACTIVITIES; VASCULAR STENTS; IN-VITRO; RELEASE; TABLETS; HYDROGELS; MICRONEEDLES; SCAFFOLDS; INKJET;
D O I：
10.1007/s42242-021-00157-0
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Since the start of the Precision Medicine Initiative by the United States of America in 2015, interest in personalized medicine has grown extensively. In short, personalized medicine is a term that describes medical treatment that is tuned to the individual. One possible way to realize personalized medicine is 3D printing. When using materials that can be tuned upon stimulation, 4D printing is established. In recent years, many studies have been exploring a new field that combines 3D and 4D printing with therapeutics. This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and, possibly, tailored to an individual. Moreover, the first 3D printed drug, Spritam (R), has already found its way to the clinic. This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine. [GRAPHICS] .
引用
收藏
页码：85 / 106
页数：22
相关论文
共 50 条
  • [31] 3D printing for drug delivery and biomedical applications
    Beg, Sarwar
    Almalki, Waleed H.
    Malik, Arshi
    Farhan, Mohd
    Aatif, Mohammad
    Rahman, Ziyaur
    Alruwaili, Nabil K.
    Alrobaian, Majed
    Tarique, Mohammed
    Rahman, Mahfoozur
    DRUG DISCOVERY TODAY, 2020, 25 (09) : 1668 - 1681
  • [32] Reverse Engineering and 3D Printing of Medical Devices for Drug Delivery and Drug-Embedded Anatomic Implants
    Elumalai, Anusha
    Nayak, Yash
    Ganapathy, Aravinda K.
    Chen, David
    Tappa, Karthik
    Jammalamadaka, Udayabhanu
    Bishop, Grace
    Ballard, David H.
    POLYMERS, 2023, 15 (21)
  • [33] Modifying release characteristics from 3D printed drug-eluting products
    Boetker, Johan
    Water, Jorrit Jeroen
    Aho, Johanna
    Arnfast, Laerke
    Bohr, Adam
    Rantanen, Jukka
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 90 : 47 - 52
  • [34] 4D Printing of Hydrogels: Innovation in Material Design and Emerging Smart Systems for Drug Delivery
    Tran, Tuan Sang
    Balu, Rajkamal
    Mettu, Srinivas
    Choudhury, Namita Roy
    Dutta, Naba Kumar
    PHARMACEUTICALS, 2022, 15 (10)
  • [35] The comprehensive review on 3D printing- pharmaceutical drug delivery and personalized food and nutrition
    Murugan, Meenakshi
    Ramasamy, Selva Kumar
    Venkatesan, Geetha
    Lee, Jintae
    Barathi, Selvaraj
    Kandasamy, Sabariswaran
    Sarangi, Prakash Kumar
    FOOD CHEMISTRY, 2024, 459
  • [36] Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems
    Mahmoud, Dina B.
    Schulz-Siegmund, Michaela
    ADVANCED HEALTHCARE MATERIALS, 2023, 12 (10)
  • [37] On -demand fully customizable drug tablets via 3D printing technology for personalized medicine
    Tan, Yan Jie Neriah
    Yong, Wai Pong
    Kochhar, Jaspreet Singh
    Khanolkar, Jayant
    Yao, Xiukai
    Sun, Yajuan
    Ao, Chi Kit
    Soh, Siowling
    JOURNAL OF CONTROLLED RELEASE, 2020, 322 (322) : 42 - 52
  • [38] Production and evaluation of polymer filaments for potential use in 3D printing of bioresorbable drug-eluting stents
    Logar, Mirta
    Prebeg, Teodora
    Fiala, Emanuel-Nino
    Vrsaljko, Domagoj
    Matijasic, Gordana
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2025, 104
  • [39] 4D printing: innovative solutions and technological advances in orthopedic repair and reconstruction, personalized treatment and drug delivery
    Shen, Chenxi
    Shen, Aiyong
    BIOMEDICAL ENGINEERING ONLINE, 2025, 24 (01)
  • [40] Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug Delivery
    Kutlehria, Shallu
    D'Souza, Anisha
    Bleier, Benjamin S.
    Amiji, Mansoor M.
    MOLECULAR PHARMACEUTICS, 2022, 19 (12) : 4411 - 4427
12345