From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery systems and personalized medicine

被引：30
|
作者：
Willemen, Niels G. A. [1 ,2 ]
Morsink, Margaretha A. J. [1 ,2 ,3 ]
Veerman, Devin [4 ]
da Silva, Classius F. [5 ]
Cardoso, Juliana C. [6 ,7 ]
Souto, Eliana B. [8 ,9 ]
Severino, Patricia [1 ,6 ,7 ,10 ]
机构：
[1] Harvard Med Sch, Brigham & Women & Hosp, Dept Med, Ctr Biomed Engn, 65 Landsdowne St, Cambridge, MA 02139 USA
[2] Univ Twente, Fac Sci & Technol, Dept Dev BioEngn, Tech Med Ctr, Enschede, Netherlands
[3] Univ Twente, Fac Sci & Technol, Dept Med Cell BioPhys, Tech Med Ctr,Translat Liver Res, Enschede, Netherlands
[4] Univ Twente, Fac Sci & Technol, Dept Biomat Sci & Technol, Targeted Therapeut, Enschede, Netherlands
[5] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Chem Engn, Rua Sao Nicolau 210, BR-09913030 Diadema, Brazil
[6] Univ Tiradentes Unit, Av Murilo Dantas 300, BR-49010390 Aracaju, Brazil
[7] Inst Technol & Res ITP, Av Murilo Dantas 300, BR-49010390 Aracaju, Brazil
[8] Univ Coimbra, Fac Pharm, Polo Ciencias Saude, Azinhaga Santa Comba, P-3000548 Coimbra, Portugal
[9] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
[10] Tiradentes Inst, 150 Mt Vernon St, Dorchester, MA 02125 USA
来源：
BIO-DESIGN AND MANUFACTURING | 2022年 / 5卷 / 01期
关键词：
Drug delivery systems; 3D/4D printing; Drug-eluting implants; Microneedles; Oral formulations; SHAPE-MEMORY POLYURETHANE; BIOLOGICAL-ACTIVITIES; VASCULAR STENTS; IN-VITRO; RELEASE; TABLETS; HYDROGELS; MICRONEEDLES; SCAFFOLDS; INKJET;
D O I：
10.1007/s42242-021-00157-0
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Since the start of the Precision Medicine Initiative by the United States of America in 2015, interest in personalized medicine has grown extensively. In short, personalized medicine is a term that describes medical treatment that is tuned to the individual. One possible way to realize personalized medicine is 3D printing. When using materials that can be tuned upon stimulation, 4D printing is established. In recent years, many studies have been exploring a new field that combines 3D and 4D printing with therapeutics. This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and, possibly, tailored to an individual. Moreover, the first 3D printed drug, Spritam (R), has already found its way to the clinic. This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine. [GRAPHICS] .
引用
收藏
页码：85 / 106
页数：22
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