Novel micromachined silicon sensor for continuous glucose monitoring

被引：40

作者：

Piechotta, G ^{[1
]}

Albers, J ^{[1
]}

Hintsche, R ^{[1
]}

机构：

[1] Fraunhofer Inst Silicon Technol, D-25524 Itzehoe, Germany

来源：

BIOSENSORS & BIOELECTRONICS | 2005年 / 21卷 / 05期

关键词：

glucose sensor; micromachined silicon; continuous measurement; diffusion control; signal stability; clinical trials;

D O I：

10.1016/j.bios.2005.02.008

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The construction and the application properties of a micromachined silicon sensor for continuous glucose monitoring are presented. The sensor uses the conventional enzymatic conversion of glucose with amperometric detection of H2O2. The innovation is the precise diffusion control of the analyte through a porous silicon membrane into a silicon etched cavity containing the immobilised enzyme. A variation of the number and size of the membrane pores allows to adjust the linear range of the sensor to the respective requirement. The sensor was tested in vitro as well as in clinical studies, being supplied with interstitial fluid. The cavity sensor was designed for a linear range between 0.5 and 20 mM. A signal response time of below 30 s and a signal stability exceeding 1 week is shown. By using a double cavity sensor falsification of the glucose signal by interfering substances can be compensated. In clinical trials the sensor measured continuously in interstitial fluid for up to 18 h without any signal drift and with good correlation to blood glucose reference values. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：802 / 808

页数：7

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