Electrochemical Oxidative C-C Bond Cleavage of Ketones for C-N Bond Formation: A Route to Amides

被引：17
|
作者：
He, Yonghui [1 ,2 ]
Zeng, Liang [1 ,2 ]
Li, Ming [1 ,2 ]
Gu, Lijun [1 ,2 ,3 ]
Zhang, Shengyong [1 ,2 ]
Li, Ganpeng [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China
[3] Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 19期
基金：
中国国家自然科学基金;
关键词：
METHYL KETONES; METAL-FREE; DIRECT TRANSFORMATION; OXYGENATION; ALDEHYDES;
D O I：
10.1021/acs.joc.2c01025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report an efficient electrochemical activation of the C-C bond of aryl ketones for the preparation of amides under catalyst-and external-oxidant-free conditions using aliphatic amines as the N source. Under environmentally benign electrolysis conditions, a series of amides were synthesized in good yield. Our control experiments revealed that electricity plays an important role in this transformation.
引用
收藏
页码：12622 / 12631
页数：10
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