Electrochemical Oxidative C-C Bond Cleavage of Ketones for C-N Bond Formation: A Route to Amides

被引：17

作者：

He, Yonghui ^{[1
,2
]}

Zeng, Liang ^{[1
,2
]}

Li, Ming ^{[1
,2
]}

Gu, Lijun ^{[1
,2
,3
]}

Zhang, Shengyong ^{[1
,2
]}

Li, Ganpeng ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China

[3] Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 19期

基金：

中国国家自然科学基金;

关键词：

METHYL KETONES; METAL-FREE; DIRECT TRANSFORMATION; OXYGENATION; ALDEHYDES;

D O I：

10.1021/acs.joc.2c01025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an efficient electrochemical activation of the C-C bond of aryl ketones for the preparation of amides under catalyst-and external-oxidant-free conditions using aliphatic amines as the N source. Under environmentally benign electrolysis conditions, a series of amides were synthesized in good yield. Our control experiments revealed that electricity plays an important role in this transformation.

引用

页码：12622 / 12631

页数：10

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