Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

被引：44
|
作者：
Nguyen, Thi Ngoc Anh [1 ]
Dao, Trong Tuan [1 ]
Tung, Bui Thanh [1 ]
Choi, Hwanwon [2 ]
Kim, Eunhee [2 ]
Park, Junsoo [3 ]
Lim, Seong-Il [4 ]
Oh, Won Keun [1 ]
机构：
[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea
[2] Choong Ang Vaccine Lab, Taejon 305348, South Korea
[3] Yonsei Univ, Div Biol Sci & Technol, Wonju 220100, South Korea
[4] Korea Food Res Inst, Tradit Food Res Grp, Songnam 463746, South Korea
来源：
FOOD CHEMISTRY | 2011年 / 124卷 / 02期
关键词：
Influenza A; Neuraminidase inhibitors; Oseltamivir resistance; Vitis amurensis; Oligostilbenes; COMBINATION THERAPY; VIRUS INFECTION; VINIFERA KYOHOU; OLIGOSTILBENES; MICE; RESVERATROL; RIMANTADINE; COIGNETIAE; ROOTS; CELLS;
D O I：
10.1016/j.foodchem.2010.06.049
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：437 / 443
页数：7
相关论文
共 50 条
  • [41] Neuraminidase Inhibitors and Hospital Mortality in British Patients with H1N1 Influenza A: A Re-Analysis of Observational Data
    Wolkewitz, Martin
    Schumacher, Martin
    PLOS ONE, 2016, 11 (09):
  • [42] QSAR model for predicting neuraminidase inhibitors of influenza A viruses (H1N1) based on adaptive grasshopper optimization algorithm
    Algamal, Z. Y.
    Qasim, M. K.
    Lee, M. H.
    Ali, H. T. M.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2020, 31 (11) : 803 - 814
  • [43] Computational model for analyzing the evolutionary patterns of the neuraminidase gene of influenza A/H1N1
    Ahn, Insung
    Son, Hyeon Seok
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2012, 36 : 23 - 30
  • [44] In silico modification of oseltamivir as neuraminidase inhibitor of influenza A virus subtype H1N1
    Usman Sumo Friend Tambunan
    Rizky Archintya Rachmania
    Arli Aditya Parikesit
    TheJournalofBiomedicalResearch, 2015, 29 (02) : 150 - 159
  • [45] In silico modification of oseltamivir as neuraminidase inhibitor of influenza A virus subtype H1N1
    Tambunan, Usman Sumo Friend
    Rachmania, Rizky Archintya
    Parikesit, Arli Aditya
    JOURNAL OF BIOMEDICAL RESEARCH, 2015, 29 (02): : 150 - 159
  • [46] Homology Modelling and Insilico Analysis of Neuraminidase Protein in H1N1 Influenza A Virus
    Manohar, Abhilash
    BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, 2011, 54 (01) : 15 - 23
  • [47] ANTIGENIC SPECIFICITY OF NEURAMINIDASE, AND GENE STRUCTURE OF NEURAMINIDASE OF INFLUENZA A (H1N1, SEROVARIANT HSW1N1) VIRUSES ISOLATED FROM MAN AND ANIMALS
    CHUVAKOVA, ZK
    DEMIYANENKO, IV
    CHAIKA, OV
    SHILOV, AA
    KIM, EV
    ROVNOVA, ZI
    ISAEVA, EI
    ISAEVA, ES
    VOPROSY VIRUSOLOGII, 1989, (06) : 656 - &
  • [48] Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
    Baltina, Lidia A.
    Zarubaev, Vladimir V.
    Baltina, Lia A.
    Orshanskaya, Iana A.
    Fairushina, Alina I.
    Kiselev, Oleg I.
    Yunusov, Marat S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (08) : 1742 - 1746
  • [49] Lessons From Outbreaks of H1N1 Influenza
    Stein, Richard A.
    ANNALS OF INTERNAL MEDICINE, 2009, 151 (01) : 59 - 62
  • [50] Influenza A/H1N1 from a pig perspective
    Nava-Ocampo, Alejandro A.
    Yadira Velazquez-Armenta, E.
    Alonso-Spilsbury, Maria
    Mota-Rojas, Daniel
    CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE, 2009, 50 (07): : 773 - 774
12345