Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

被引：44
|
作者：
Nguyen, Thi Ngoc Anh [1 ]
Dao, Trong Tuan [1 ]
Tung, Bui Thanh [1 ]
Choi, Hwanwon [2 ]
Kim, Eunhee [2 ]
Park, Junsoo [3 ]
Lim, Seong-Il [4 ]
Oh, Won Keun [1 ]
机构：
[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea
[2] Choong Ang Vaccine Lab, Taejon 305348, South Korea
[3] Yonsei Univ, Div Biol Sci & Technol, Wonju 220100, South Korea
[4] Korea Food Res Inst, Tradit Food Res Grp, Songnam 463746, South Korea
来源：
FOOD CHEMISTRY | 2011年 / 124卷 / 02期
关键词：
Influenza A; Neuraminidase inhibitors; Oseltamivir resistance; Vitis amurensis; Oligostilbenes; COMBINATION THERAPY; VIRUS INFECTION; VINIFERA KYOHOU; OLIGOSTILBENES; MICE; RESVERATROL; RIMANTADINE; COIGNETIAE; ROOTS; CELLS;
D O I：
10.1016/j.foodchem.2010.06.049
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：437 / 443
页数：7
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