Targeting novel signaling pathways for resistant acute myeloid leukemia

被引：58

作者：

Sakamoto, Kathleen M. ^{[1
]}

Grant, Steven ^{[2
]}

Saleiro, Diana ^{[3
,4
]}

Crispino, John D. ^{[3
,4
]}

Hijiya, Nobuko ^{[6
]}

Giles, Francis ^{[3
,4
]}

Platanias, Leonidas ^{[3
,4
,5
]}

Eklund, Elizabeth A. ^{[3
,4
,5
]}

机构：

[1] Stanford Univ, Dept Pediat, Sch Med, Div Hematol Oncol, Stanford, CA 94305 USA

[2] Virginia Commonwealth Univ, Dept Med, Sch Med, Div Hematol Oncol & Palliat Care, Richmond, VA 23298 USA

[3] Northwestern Univ, Med Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Med, Med Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

[5] Jesse Brown Vet Affairs Med Ctr, Dept Med, Div Hematol Oncol, Chicago, IL USA

[6] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2015年 / 114卷 / 03期

关键词：

Acute myeloid leukemia; Signaling pathways; Novel therapies; Resistance; ELEMENT-BINDING-PROTEIN; UBIQUITIN LIGASE TRIAD1; GENE-EXPRESSION; TYROSINE-PHOSPHATASE; ENCODING GP91(PHOX); BCL-2; INHIBITION; CLONAL EVOLUTION; DUAL INHIBITION; JAK INHIBITORS; CREB;

D O I：

10.1016/j.ymgme.2014.11.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：397 / 402

页数：6

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