Targeting novel signaling pathways for resistant acute myeloid leukemia

被引：58

作者：

Sakamoto, Kathleen M. ^{[1
]}

Grant, Steven ^{[2
]}

Saleiro, Diana ^{[3
,4
]}

Crispino, John D. ^{[3
,4
]}

Hijiya, Nobuko ^{[6
]}

Giles, Francis ^{[3
,4
]}

Platanias, Leonidas ^{[3
,4
,5
]}

Eklund, Elizabeth A. ^{[3
,4
,5
]}

机构：

[1] Stanford Univ, Dept Pediat, Sch Med, Div Hematol Oncol, Stanford, CA 94305 USA

[2] Virginia Commonwealth Univ, Dept Med, Sch Med, Div Hematol Oncol & Palliat Care, Richmond, VA 23298 USA

[3] Northwestern Univ, Med Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Med, Med Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

[5] Jesse Brown Vet Affairs Med Ctr, Dept Med, Div Hematol Oncol, Chicago, IL USA

[6] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2015年 / 114卷 / 03期

关键词：

Acute myeloid leukemia; Signaling pathways; Novel therapies; Resistance; ELEMENT-BINDING-PROTEIN; UBIQUITIN LIGASE TRIAD1; GENE-EXPRESSION; TYROSINE-PHOSPHATASE; ENCODING GP91(PHOX); BCL-2; INHIBITION; CLONAL EVOLUTION; DUAL INHIBITION; JAK INHIBITORS; CREB;

D O I：

10.1016/j.ymgme.2014.11.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：397 / 402

页数：6

共 50 条

[21] Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia
Cicek, Enes
Kucuktas, Fulya Mina
Yenigul, Munevver
Akcok, Emel Basak Gencer
EXPERIMED, 2022, 12 (03): : 202 - 208
[22] Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia
Chapuis, Nicolas
Poulain, Laury
Birsen, Rudy
Tamburini, Jerome
Bouscary, Didier
FRONTIERS IN ONCOLOGY, 2019, 9
[23] Novel Therapeutic Targeting of UHRF1 Restores 5′-Azacytidine Response in Resistant Acute Myeloid Leukemia
Singh, Anup Kumar
Yu, Xiaochun
BLOOD, 2018, 132
[24] Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia
Alharbi, Homood
Ahmad, Mohammad
Cui, Zhong
Meng, Dong
Xin, Ying
Yan, Xues
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2025, 47 (02) : 288 - 296
[25] Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia
Chiriches, Claudia
Khan, Dilawar
Wieske, Maria
Guillen, Nathalie
Rokicki, Michal
Guy, Carol
Wilson, Marieangela
Heesom, Kate J.
Ottmann, Oliver Gerhard
Ruthardt, Martin
ANNALS OF HEMATOLOGY, 2022, 101 (10) : 2179 - 2193
[26] Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia
Claudia Chiriches
Dilawar Khan
Maria Wieske
Nathalie Guillen
Michal Rokicki
Carol Guy
Marieangela Wilson
Kate J. Heesom
Oliver Gerhard Ottmann
Martin Ruthardt
Annals of Hematology, 2022, 101 : 2179 - 2193
[27] Targeting neurolysin in acute myeloid leukemia
Mirali, Sara
Schimmer, Aaron D.
MOLECULAR & CELLULAR ONCOLOGY, 2020, 7 (04)
[28] Targeting the Microenvironment in Acute Myeloid Leukemia
Rashidi, Armin
Uy, Geoffrey L.
CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2015, 10 (02) : 126 - 131
[29] Molecular targeting in acute myeloid leukemia
Seah H. Lim
Patrycja M. Dubielecka
Vikram M. Raghunathan
Journal of Translational Medicine, 15
[30] Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
Aberger, Fritz
Hutterer, Evelyn
Sternberg, Christina
del Burgo, Pedro J.
Hartmann, Tanja N.
CELL COMMUNICATION AND SIGNALING, 2017, 15

← 1 2 3 4 5 →