Amino acids and peptides .48. Studies on the structure of an unexpected reaction product from dipeptidyl chloromethyl ketone during acid hydrolysis

被引：3

作者：

Yokoi, T ^{[1
]}

Taguchi, H ^{[1
]}

Nishiyama, Y ^{[1
]}

Igarashi, K ^{[1
]}

Kasuya, F ^{[1
]}

Okada, Y ^{[1
]}

机构：

[1] KOBE GAKUIN UNIV, FAC PHARMACEUT SCI, NISHI KU, KOBE 65121, JAPAN

来源：

JOURNAL OF CHEMICAL RESEARCH | 1997年 / 01期

关键词：

D O I：

10.1039/a606548a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

During the course of the synthesis of peptidyl chloromethyl ketones (CMKs), it was revealed that aminoacid recovery after acid hydrolysis (6 mol dm(-3) HCl, 110 degrees C, 20 h) of dipeptidyl chloromethyl ketones was markedly low (7.1-33.7%) owing to the formation of 5-methylpyrazin-2(1H)-one derivatives during the acid hydrolysis.

引用

页码：10 / 11

页数：2

共 37 条

[31] BIOCHEMICAL STUDIES ON HEMOGLOBINS AND MYOGLOBINS .1. AMINO ACID COMPOSITIONS AND N-TERMINAL AMINO ACIDS OF ALL TRYPTIC PEPTIDES FROM ALPHA AND BETA POLYPEPTIDE CHAINS OF ADULT HEMOGLOBIN OF RHESUS MONKEY (MACACA-MULATTA)
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[35] X-RAY STUDIES ON CRYSTALLINE COMPLEXES INVOLVING AMINO-ACIDS AND PEPTIDES .18. CRYSTAL-STRUCTURE OF A NEW FORM OF L-ARGININE D-GLUTAMATE AND A COMPARATIVE-STUDY OF AMINO-ACID CRYSTAL-STRUCTURES CONTAINING MOLECULES OF THE SAME AND MIXED CHIRALITY
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