Amino acids and peptides .48. Studies on the structure of an unexpected reaction product from dipeptidyl chloromethyl ketone during acid hydrolysis

被引：3
|
作者：
Yokoi, T [1 ]
Taguchi, H [1 ]
Nishiyama, Y [1 ]
Igarashi, K [1 ]
Kasuya, F [1 ]
Okada, Y [1 ]
机构：
[1] KOBE GAKUIN UNIV, FAC PHARMACEUT SCI, NISHI KU, KOBE 65121, JAPAN
来源：
JOURNAL OF CHEMICAL RESEARCH | 1997年 / 01期
关键词：
D O I：
10.1039/a606548a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
During the course of the synthesis of peptidyl chloromethyl ketones (CMKs), it was revealed that aminoacid recovery after acid hydrolysis (6 mol dm(-3) HCl, 110 degrees C, 20 h) of dipeptidyl chloromethyl ketones was markedly low (7.1-33.7%) owing to the formation of 5-methylpyrazin-2(1H)-one derivatives during the acid hydrolysis.
引用
收藏
页码：10 / 11
页数：2
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