Synthesis of 3-Substituted Indazoles from Arynes and N-Tosylhydrazones

被引：105
|
作者：
Li, Pan [1 ]
Zhao, Jingjing [1 ]
Wu, Chunrui [1 ]
Larock, Richard C. [2 ]
Shi, Feng [1 ]
机构：
[1] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China
[2] Iowa State Univ, Dept Chem, Ames, IA 50010 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 13期
基金：
中国国家自然科学基金;
关键词：
BAMFORD-STEVENS REACTION; GENERATED IN-SITU; DIAZO-COMPOUNDS; 1,3-DIPOLAR CYCLOADDITION; 1H-INDAZOLES; DERIVATIVES; SELECTIVITY; SALTS;
D O I：
10.1021/ol201086g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to good yields. The reaction appears to involve a dipolar cycloaddition of in situ generated diazo compounds and arynes.
引用
收藏
页码：3340 / 3343
页数：4
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