Synthesis of 3-Substituted Indazoles from Arynes and N-Tosylhydrazones

被引：105

作者：

Li, Pan ^{[1
]}

Zhao, Jingjing ^{[1
]}

Wu, Chunrui ^{[1
]}

Larock, Richard C. ^{[2
]}

Shi, Feng ^{[1
]}

机构：

[1] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China

[2] Iowa State Univ, Dept Chem, Ames, IA 50010 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 13期

基金：

中国国家自然科学基金;

关键词：

BAMFORD-STEVENS REACTION; GENERATED IN-SITU; DIAZO-COMPOUNDS; 1,3-DIPOLAR CYCLOADDITION; 1H-INDAZOLES; DERIVATIVES; SELECTIVITY; SALTS;

D O I：

10.1021/ol201086g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to good yields. The reaction appears to involve a dipolar cycloaddition of in situ generated diazo compounds and arynes.

引用

页码：3340 / 3343

页数：4

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