Chiral iminophosphorane catalyzed asymmetric sulfenylation of 4-substituted pyrazolones

被引：28

作者：

Han, Jianwei ^{[1
,2
]}

Zhang, Yanxia ^{[1
,2
]}

Wu, Xin-Yan ^{[1
]}

Wong, Henry N. C. ^{[2
]}

机构：

[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 03期

基金：

中国国家自然科学基金;

关键词：

MICHAEL ADDITION; STEREOCONTROLLED CONSTRUCTION; ENANTIOSELECTIVITY; PYRAZOL-5-ONES; TEMPERATURE; ALKYLATION; QUATERNARY; PYRAZOLIN-5-ONES; PALLADIUM; KETONES;

D O I：

10.1039/c8cc09049a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An excellent level of enantioselectivity in asymmetric sulfenylation of 4-substituted pyrazolones was achieved with chiral iminophosphorane as the organocatalyst under continuum solvation conditions (up to 99% ee). Importantly, this catalytic process features high efficiency with excellent enantioselectivities, easy separation of products, low catalytic loadings and scale-up to grams without loss of enantioselectivity.

引用

页码：397 / 400

页数：4

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