ASYMMETRIC SYNTHESIS OF 4-SUBSTITUTED 2,6-DIOXOPIPERIDINE-3-CARBONITRILE BY USING THIOUREA-CATALYZED ASYMMETRIC MICHAEL ADDITION

被引：9
|
作者：
Inokuma, Tsubasa [1 ]
Nagamoto, Yuuki [1 ]
Sakamoto, Shota [1 ]
Miyabe, Hideto [1 ]
Takasu, Kiyosei [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
HETEROCYCLES | 2009年 / 79卷
关键词：
Michael Reaction; Asymmetric Organocatalysis; Hydrogen Bond; Bifunctional Thiourea; Piperidine; ENANTIOSELECTIVE CONJUGATE ADDITION; ORGANOCATALYST; CHALCONES; MALONONITRILE;
D O I：
10.3987/COM-08-S(D)18
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective Michael addition of several alpha,beta-unsaturated carbonyl compounds with malononitrile catalyzed by a bifunctional thiourea is described. We also demonstrate the transformation of Michael adduct into an enantiomerically enriched functionalized piperidine.
引用
收藏
页码：573 / 582
页数：10
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