Ionizing radiation attracts tumor targeting and apoptosis by radiotropic lysyl oxidase traceable nanoparticles

被引：11

作者：

Cho, Wheemoon ^{[1
,5
,6
]}

Kim, Min Sup ^{[1
]}

Lee, Kee-Ho ^{[2
]}

Park, Sang Jun ^{[1
]}

Shin, Hyun-Jin ^{[2
]}

Lee, Yong Jin ^{[3
]}

Kim, Sang Bum ^{[4
]}

Son, Youngsook ^{[5
,6
]}

Kim, Chun-Ho ^{[1
]}

机构：

[1] Korea Inst Radiol & Med Sci, Lab Tissue Engn, Seoul 01812, South Korea

[2] Korea Inst Radiol & Med Sci, Div Radiat Canc Res, Seoul, South Korea

[3] Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul, South Korea

[4] Korea Inst Radiol & Med Sci, Dept Surg, Seoul, South Korea

[5] Kyung Hee Univ, Coll Life Sci, Dept Genet Engn, Yongin, South Korea

[6] Kyung Hee Univ, Grad Sch Biotechnol, Yongin, South Korea

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2020年 / 24卷

基金：

新加坡国家研究基金会;

关键词：

LOX-traceable nanoparticles; Radiotropic; Stimulus inducible; Targeting; Ionizing radiation; Chemo-radiotherapy; ALBUMIN-BOUND PACLITAXEL; CELL LUNG-CANCER; CONCURRENT CHEMORADIOTHERAPY; NEOADJUVANT CHEMOTHERAPY; EXTRACELLULAR-MATRIX; DRUG-DELIVERY; RADIOTHERAPY; NANOMEDICINE; MODELS; RADIORESISTANCE;

D O I：

10.1016/j.nano.2019.102141

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Lysyl oxidase (LOX) is a cell-secreted amine oxidase that crosslinks collagen and elastin in extracellular microenvironment. LOX-traceable nanoparticles (LOXab-NPs) consisting of LOX antibodies (LOXab) and paclitaxel, can accumulate at high concentrations at radiation-treated target sites, as a tumor-targeting drug carrier for chemotherapy. Tumor-targeting and anticancer effects of PLGA based LOXab-NPs in vitro and in vivo were evaluated at radiation-targeted site. In the in vivo A549 lung carcinoma xenograft model, we showed highly specific tumor targeting (above 7.0 times higher) of LOXab-NPs on irradiated tumors. Notably, systemically administered NPs delayed tumor growth, reducing tumor volumes by more than 2 times compared with non-irradiated groups (222% vs. N500%) over 2 weeks. Radiotropic LOXab-NPs can serve as chemotherapeutic vehicles for combined targeted chemo-radiotherapy in clinical oncology. (C) 2019 Elsevier Inc. All rights reserved.

引用

页数：12

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