Ionizing radiation attracts tumor targeting and apoptosis by radiotropic lysyl oxidase traceable nanoparticles

被引：11
|
作者：
Cho, Wheemoon [1 ,5 ,6 ]
Kim, Min Sup [1 ]
Lee, Kee-Ho [2 ]
Park, Sang Jun [1 ]
Shin, Hyun-Jin [2 ]
Lee, Yong Jin [3 ]
Kim, Sang Bum [4 ]
Son, Youngsook [5 ,6 ]
Kim, Chun-Ho [1 ]
机构：
[1] Korea Inst Radiol & Med Sci, Lab Tissue Engn, Seoul 01812, South Korea
[2] Korea Inst Radiol & Med Sci, Div Radiat Canc Res, Seoul, South Korea
[3] Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul, South Korea
[4] Korea Inst Radiol & Med Sci, Dept Surg, Seoul, South Korea
[5] Kyung Hee Univ, Coll Life Sci, Dept Genet Engn, Yongin, South Korea
[6] Kyung Hee Univ, Grad Sch Biotechnol, Yongin, South Korea
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2020年 / 24卷
基金：
新加坡国家研究基金会;
关键词：
LOX-traceable nanoparticles; Radiotropic; Stimulus inducible; Targeting; Ionizing radiation; Chemo-radiotherapy; ALBUMIN-BOUND PACLITAXEL; CELL LUNG-CANCER; CONCURRENT CHEMORADIOTHERAPY; NEOADJUVANT CHEMOTHERAPY; EXTRACELLULAR-MATRIX; DRUG-DELIVERY; RADIOTHERAPY; NANOMEDICINE; MODELS; RADIORESISTANCE;
D O I：
10.1016/j.nano.2019.102141
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Lysyl oxidase (LOX) is a cell-secreted amine oxidase that crosslinks collagen and elastin in extracellular microenvironment. LOX-traceable nanoparticles (LOXab-NPs) consisting of LOX antibodies (LOXab) and paclitaxel, can accumulate at high concentrations at radiation-treated target sites, as a tumor-targeting drug carrier for chemotherapy. Tumor-targeting and anticancer effects of PLGA based LOXab-NPs in vitro and in vivo were evaluated at radiation-targeted site. In the in vivo A549 lung carcinoma xenograft model, we showed highly specific tumor targeting (above 7.0 times higher) of LOXab-NPs on irradiated tumors. Notably, systemically administered NPs delayed tumor growth, reducing tumor volumes by more than 2 times compared with non-irradiated groups (222% vs. N500%) over 2 weeks. Radiotropic LOXab-NPs can serve as chemotherapeutic vehicles for combined targeted chemo-radiotherapy in clinical oncology. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页数：12
相关论文
共 50 条
  • [31] Critical role of glutathione in melatonin enhancement of tumor necrosis factor and ionizing radiation-induced apoptosis in prostate cancer cells in vitro
    Sainz, Rosa M.
    Reiter, Russel J.
    Tan, Dun-Xian
    Roldan, Francis
    Natarajan, Mohan
    Quiros, Isabel
    Hevia, David
    Rodriguez, Carmen
    Mayo, Juan C.
    JOURNAL OF PINEAL RESEARCH, 2008, 45 (03) : 258 - 270
  • [32] miR-335 Acts as a Tumor Suppressor and Enhances Ionizing Radiation-Induced Tumor Regression by Targeting ROCK1 (vol 10, 278, 2020)
    Cheng, Yanfeng
    Shen, Peng
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [33] Fucoidan-Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Co-Targeting Tumor Hypoxia and Angiogenesis
    Shin, Sung-Won
    Jung, Wooju
    Choi, Changhoon
    Kim, Shin-Yeong
    Son, Arang
    Kim, Hakyoung
    Lee, Nohyun
    Park, Hee Chul
    MARINE DRUGS, 2018, 16 (12)
  • [34] Influence of Gold-coated Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines in Combination Therapy with ionizing Radiation
    Franzen, T.
    Schreiber, C.
    Fietkau, R.
    Tietze, R.
    Stein, R.
    Friedrich, B.
    Distel, L.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2021, 197 (SUPPL 1) : S123 - S123
  • [35] Impact of Citrate-stabilized superparamagnetic Iron Oxide-Nanoparticles on Head and Neck Tumor Cell Lines in Combination Therapy with ionizing Radiation
    Schreiber, C.
    Franzen, T.
    Fietkau, R.
    Tietze, R.
    Stein, R.
    Friedrich, B.
    Distel, L.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2021, 197 (SUPPL 1) : S111 - S111
  • [36] Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack
    Cacan, Ercan
    Spring, Alexander M.
    Kumari, Anita
    Greer, Susanna F.
    Garnett-Benson, Charlie
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (12): : 30405 - 30421
  • [37] Recombinant mistletoe-lectin induces p53-independent apoptosis in tumor cells and cooperates with ionizing radiation induced cell kill.
    Hostanska, K
    Vuong, V
    Rocha, S
    Glanzmann, C
    Bodis, S
    Saller, R
    Pruschy, M
    CLINICAL CANCER RESEARCH, 2000, 6 : 4540S - 4540S
  • [38] Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand
    Nagane, Motoo
    Cavenee, Webster K.
    Shiokawa, Yoshiaki
    JOURNAL OF NEUROSURGERY, 2007, 106 (03) : 407 - 416
  • [39] Tumor Targeting and Cancer Cell Penetrating Theranostic Gadolinium Nanoparticles for Image-Guided Nanoparticle-Enhanced Radiation Therapy
    Liu, W.
    Deacon, J.
    Yan, H.
    Sun, B.
    Liu, Y.
    Hegan, D.
    Roberts, K.
    Glazer, P.
    Chen, Z.
    Nath, R.
    MEDICAL PHYSICS, 2018, 45 (06) : E147 - E147
  • [40] The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice
    Sundaram, S
    Sea, A
    Feldman, S
    Strawbridge, R
    Hoopes, PJ
    Demidenko, E
    Binderup, L
    Gewirtz, DA
    CLINICAL CANCER RESEARCH, 2003, 9 (06) : 2350 - 2356
12345