BrainProfileDB - a platform for integration of functional genomics data

被引:7
|
作者
Schuchhardt, Johannes [1 ]
Glintschert, Alexander [1 ]
Hartl, Daniela [2 ]
Irmler, Martin [3 ]
Beckers, Johannes [3 ,4 ]
Stephan, Christian [5 ]
Marcus, Katrin [5 ]
Klose, Joachim [2 ]
Meyer, Helmut E. [5 ]
Malik, Arif [1 ]
机构
[1] Microdiscovery GmbH, D-10405 Berlin, Germany
[2] Charite, Inst Human Genet, D-13353 Berlin, Germany
[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Expt Genet, Neuherberg, Germany
[4] Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, Chair Expt Genet, Weihenstephan, Germany
[5] Ruhr Univ Bochum, Med Proteom Ctr, Bochum, Germany
关键词
data analysis; functional genomics database; high-throughput data management; integrating genomics and proteomics; neurodegenerative diseases;
D O I
10.1002/pmic.200700743
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
BrainProfileDB is a database system for integrating large sets of high throughput functional genomics data of the Human Brain Proteome Project (HBPP). Within HBPP (http://www.smp.proteomics.de/) the molecular pathology of neurodegenerative diseases is investigated, using complementary methods from transcriptomics, proteomics, toponomics and interaction measurements. Aim of the database system is to provide a broad spectrum of scientific users joined in the consortium with a practical integrated view on their data. Employing appropriate mapping techniques and levels of data representation the user is relieved from technical details of gene identification or experimental measurement technique.
引用
收藏
页码:1162 / 1164
页数:3
相关论文
共 50 条
  • [1] Building a BRIDGE for the integration of heterogeneous data from functional genomics into a platform for systems biology
    Goesmann, A
    Linke, B
    Rupp, O
    Krause, L
    Bartels, D
    Dondrup, M
    McHardy, AC
    Wilke, A
    Pühler, A
    Meyer, F
    JOURNAL OF BIOTECHNOLOGY, 2003, 106 (2-3) : 157 - 167
  • [2] The ESF Programme on Functional Genomics workshop on 'Data Integration in Functional Genomics: Application to Biological Pathways
    Binz, PA
    Hermjakob, H
    van der Vet, P
    COMPARATIVE AND FUNCTIONAL GENOMICS, 2004, 5 (02): : 148 - 155
  • [3] Genomics data integration
    Lin Tang
    Nature Methods, 2023, 20 : 34 - 34
  • [4] Genomics data integration
    Tang, Lin
    NATURE METHODS, 2023, 20 (01) : 34 - 34
  • [5] Integration of structural and functional genomics
    Tuggle, C. K.
    Dekkers, J. C. M.
    Reecy, J. M.
    ANIMAL GENETICS, 2006, 37 : 1 - 6
  • [6] Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity
    Ruowang Li
    Dokyoon Kim
    Heather E. Wheeler
    Scott M. Dudek
    M. Eileen Dolan
    Marylyn D. Ritchie
    The Pharmacogenomics Journal, 2019, 19 : 178 - 190
  • [7] Predictive modelling and integration of functional genomics data for applications in plant biology
    Bylesjo, M.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2008, 150 (03): : S50 - S50
  • [8] Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity
    Li, Ruowang
    Kim, Dokyoon
    Wheeler, Heather E.
    Dudek, Scott M.
    Dolan, M. Eileen
    Ritchie, Marylyn D.
    PHARMACOGENOMICS JOURNAL, 2019, 19 (02): : 178 - 190
  • [9] Solutions for data integration in functional genomics: a critical assessment and case study
    Smedley, Damian
    Swertz, Morris A.
    Wolstencroft, Katy
    Proctor, Glenn
    Zouberakis, Michael
    Bard, Jonathan
    Hancock, John M.
    Schofield, Paul
    BRIEFINGS IN BIOINFORMATICS, 2008, 9 (06) : 532 - 544
  • [10] Index-driven XML data integration to support functional Genomics
    Hunt, E
    Pafilis, E
    Tulloch, I
    Wilson, J
    DATA INTEGRATION IN THE LIFE SCIENCES, PROCEEDINGS, 2004, 2994 : 95 - 109