Real-World Data and Physiologically-Based Mechanistic Models for Precision Medicine

被引：3

作者：

Wang, Ken ^{[1
]}

Parrott, Neil ^{[1
]}

Olivares-Morales, Andres ^{[1
]}

Dudal, Sherri ^{[1
]}

Singer, Thomas ^{[1
]}

Lave, Thierry ^{[1
]}

Ribba, Benjamin ^{[1
]}

机构：

[1] Roche Pharmaceut Res & Early Dev, Roche Innovat Ctr Basel, Pharmaceut Sci, Basel, Switzerland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷 / 04期

关键词：

D O I：

10.1002/cpt.1780

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The assessment of a therapeutic window for pharmaceutical compounds requires the integration of multidimensional data. In this perspective, we highlight how the increased volume of medical and healthcare data, and, in particular, real-world data (RWD), can be integrated within physiologically based modeling framework. We illustrate this perspective view with specific case studies related to pharmacokinetic and cardiac safety predictions.

引用

页码：694 / 696

页数：3

共 50 条

[41] Deploying the MS Bioscreen in the clinic: towards real-world precision medicine
Bove, R.
Lizee, A.
Garcha, P.
Hauser, S. L.
MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 674 - 674
[42] Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study
Agarwala, Vineeta
Khozin, Sean
Singal, Gaurav
O'Connell, Claire
Kuk, Deborah
Li, Gerald
Gossai, Anala
Miller, Vincent
Abernethy, Amy P.
HEALTH AFFAIRS, 2018, 37 (05) : 765 - 772
[43] Development and application of physiologically-based kinetic (PBK) models
Madden, Judith
Tan, Yu-Mei
Blaauboer, Bas
Paini, Alicia
Computational Toxicology, 2020, 13
[44] Real-world study: from real-world data to real-world evidence
Wen, Yi
TRANSLATIONAL BREAST CANCER RESEARCH, 2020, 1
[45] An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
Fairman, Kiara
Choi, Me-Kyoung
Gonnabathula, Pavani
Lumen, Annie
Worth, Andrew
Paini, Alicia
Li, Miao
TOXICS, 2023, 11 (02)
[46] Translating real-world evidence/real-world data
Ravenstijn, Paulien
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 17 (05):
[47] Cancer Models and Real-World Data: Better Together
Kim, Jane J.
Tosteson, Anna N. A.
Zauber, Ann G.
Sprague, Brian L.
Stout, Natasha K.
Alagoz, Oguzhan
Trentham-Dietz, Amy
Armstrong, Katrina
Pruitt, Sandi L.
Rutter, Carolyn M.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (02):
[48] Evidence-based medicine, opinion-based medicine, and real-world medicine
Hampton, JR
PERSPECTIVES IN BIOLOGY AND MEDICINE, 2002, 45 (04) : 549 - 568
[49] SuperpixelGridMasks Data Augmentation: Application to Precision Health and Other Real-world Data
Karim Hammoudi
Adnane Cabani
Bouthaina Slika
Halim Benhabiles
Fadi Dornaika
Mahmoud Melkemi
Journal of Healthcare Informatics Research, 2022, 6 : 442 - 460
[50] SuperpixelGridMasks Data Augmentation: Application to Precision Health and Other Real-world Data
Hammoudi, Karim
Cabani, Adnane
Slika, Bouthaina
Benhabiles, Halim
Dornaika, Fadi
Melkemi, Mahmoud
JOURNAL OF HEALTHCARE INFORMATICS RESEARCH, 2022, 6 (04) : 442 - 460

← 1 2 3 4 5 →