Real-World Data and Physiologically-Based Mechanistic Models for Precision Medicine

被引：3

作者：

Wang, Ken ^{[1
]}

Parrott, Neil ^{[1
]}

Olivares-Morales, Andres ^{[1
]}

Dudal, Sherri ^{[1
]}

Singer, Thomas ^{[1
]}

Lave, Thierry ^{[1
]}

Ribba, Benjamin ^{[1
]}

机构：

[1] Roche Pharmaceut Res & Early Dev, Roche Innovat Ctr Basel, Pharmaceut Sci, Basel, Switzerland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷 / 04期

关键词：

D O I：

10.1002/cpt.1780

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The assessment of a therapeutic window for pharmaceutical compounds requires the integration of multidimensional data. In this perspective, we highlight how the increased volume of medical and healthcare data, and, in particular, real-world data (RWD), can be integrated within physiologically based modeling framework. We illustrate this perspective view with specific case studies related to pharmacokinetic and cardiac safety predictions.

引用

页码：694 / 696

页数：3

共 50 条

[31] Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin
Bowman, Christine M.
Ma, Fang
Mao, Jialin
Chen, Yuan
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2021, 10 (01): : 5 - 17
[32] Applications of minimal physiologically-based pharmacokinetic models
Cao, Yanguang
Jusko, William J.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2012, 39 (06) : 711 - 723
[33] PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS IN DEVELOPMENTAL TOXICOLOGY
FLAHERTY, EJ
RISK ANALYSIS, 1994, 14 (04) : 605 - 611
[34] GRAPHICAL PROBABILISTIC MODELS FOR RISK PREDICTION AND DECISION MAKING USING REAL-WORLD DATA: A DEVELOPING TOOL FOR THE ERA OF PRECISION MEDICINE
Arora, P.
Boyne, D. J.
Druzdzel, M. J.
VALUE IN HEALTH, 2018, 21 : S10 - S10
[35] Next-Generation Sequencing in Breast Cancer Patients: Real-World Data for Precision Medicine
Lee, Hyunwoo
Cho, Yoon Ah
Kim, Deok Geun
Cho, Eun Yoon
CANCER RESEARCH AND TREATMENT, 2024, 56 (01): : 149 - 161
[36] Physiologically-based pharmacokinetic modelling in veterinary medicine.
Chapel, AM
Sanders, P
REVUE DE MEDECINE VETERINAIRE, 1996, 147 (05) : 359 - 366
[37] Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data
Codaccioni M.
Bois F.
Brochot C.
Computational Toxicology, 2019, 12
[38] Real-World Data as an Evidence Source in Nuclear Medicine
Bourla, Ariel B.
Herrmann, Ken
JOURNAL OF NUCLEAR MEDICINE, 2021, 62 (02) : 156 - 157
[39] Real-World Battles with Real-World Data
Brown, Jeffrey
Bate, Andrew
Platt, Robert
Raebel, Marsha
Sauer, Brian
Trifiro, Gianluca
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2017, 26 : 254 - 255
[40] Small But Mighty: The Use of Real-World Evidence to Inform Precision Medicine
Miksad, Rebecca A.
Samant, Meghna K.
Sarkar, Somnath
Abernethy, Amy P.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 106 (01) : 87 - 90

← 1 2 3 4 5 →