Synthesis of 3,3-disubstituted α-tetralones by rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols

被引：41

作者：

Ishida, Naoki ^{[1
]}

Sawano, Shota ^{[1
]}

Murakami, Masahiro ^{[1
]}

机构：

[1] Kyoto Univ, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 14期

关键词：

CARBON-CARBON BONDS; QUATERNARY STEREOGENIC CENTERS; TERT-CYCLOBUTANOLS; ARYLBORONIC ACIDS; ORGANIC-SYNTHESIS; 8-MEMBERED RINGS; ACTIVATION; CLEAVAGE; ARYL; DERIVATIVES;

D O I：

10.1039/c2cc16907j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols afforded 3,3-disubstituted alpha-tetralones. The reaction was applied to the asymmetric synthesis of alpha-tetralones bearing a chiral quaternary carbon centre at the 3-position, which was otherwise difficult to execute.

引用

页码：1973 / 1975

页数：3

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