Synthesis of 3,3-disubstituted α-tetralones by rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols

被引：41
|
作者：
Ishida, Naoki [1 ]
Sawano, Shota [1 ]
Murakami, Masahiro [1 ]
机构：
[1] Kyoto Univ, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 14期
关键词：
CARBON-CARBON BONDS; QUATERNARY STEREOGENIC CENTERS; TERT-CYCLOBUTANOLS; ARYLBORONIC ACIDS; ORGANIC-SYNTHESIS; 8-MEMBERED RINGS; ACTIVATION; CLEAVAGE; ARYL; DERIVATIVES;
D O I：
10.1039/c2cc16907j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols afforded 3,3-disubstituted alpha-tetralones. The reaction was applied to the asymmetric synthesis of alpha-tetralones bearing a chiral quaternary carbon centre at the 3-position, which was otherwise difficult to execute.
引用
收藏
页码：1973 / 1975
页数：3
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