Synthetic studies towards phorboxazole B: Stereoselective synthesis of the C3-C19 bis-oxane oxazole fragment

被引：6

作者：

Zhang, DH ^{[1
]}

Zhou, WS ^{[1
]}

机构：

[1] Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

SYNLETT | 2003年 / 12期

关键词：

enantioselective synthesis; phorboxazole; reduction; Mukaiyama reaction; Williamson reaction;

D O I：

10.1055/s-2003-41462

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent and enantioselective synthesis of the C3-C19 bis-oxane oxazole fragment of phorboxazole B has been described. This work features highly efficient substrate-controlled reductions to construct the functionalised cis-oxane and a Mukaiyama aldol reaction followed by an intramolecular Williamson reaction leading to a trans-oxane.

引用

页码：1817 / 1821

页数：5

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