Synthetic studies towards phorboxazole B: Stereoselective synthesis of the C3-C19 bis-oxane oxazole fragment

被引：6
|
作者：
Zhang, DH [1 ]
Zhou, WS [1 ]
机构：
[1] Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
SYNLETT | 2003年 / 12期
关键词：
enantioselective synthesis; phorboxazole; reduction; Mukaiyama reaction; Williamson reaction;
D O I：
10.1055/s-2003-41462
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent and enantioselective synthesis of the C3-C19 bis-oxane oxazole fragment of phorboxazole B has been described. This work features highly efficient substrate-controlled reductions to construct the functionalised cis-oxane and a Mukaiyama aldol reaction followed by an intramolecular Williamson reaction leading to a trans-oxane.
引用
收藏
页码：1817 / 1821
页数：5
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