The relationship between regulatory T cells and radiation therapy

被引：3
|
作者：
Hou, P-F [1 ]
Zhua, L-J [1 ]
Pan, Y. [1 ]
Sun, X-C [2 ]
Pu, J. [3 ]
机构：
[1] Lianshui Cty Peoples Hosp, Dept Clin Lab, Lianshui, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Nanjing, Peoples R China
[3] Lianshui Cty Peoples Hosp, Dept Radiat Oncol, Lianshui, Peoples R China
来源：
CANCER RADIOTHERAPIE | 2020年 / 24卷 / 01期
关键词：
Tregs; Radiotherapy; Cancer; Relationship; SERUM CARCINOEMBRYONIC ANTIGEN; CYFRA; 21-1; RADIOTHERAPY; SURVIVAL; METASTASIS; MECHANISMS; GAMMA;
D O I：
10.1016/j.canrad.2019.07.160
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiation therapy (RT) is an effective treatment for cancer. Approximately, 70% of cancer patients receive RT in China. The immune-modulating effect of radiation therapy have gained considerable interest in recent years and there have been multiple reports of synergy between radiation and immunotherapy. Regulatory T cells (Tregs) are a group of T cell subsets with immunosuppressive function, which is correlated with cancer. Tregs are involved in the pathogenesis, development, treatment and prognosis of tumors by cell-cell contact, cytokines, and cell metabolism. Based on the immunological characteristics of Tregs, this article reviews the interaction between RT and immune molecules, aiming to provide new ideas for RT combined with immunotherapy. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：81 / 84
页数：4
相关论文
共 50 条
  • [31] T regulatory cells turn on T regulatory cells
    Scott, David W.
    BLOOD, 2009, 114 (19) : 3975 - 3976
  • [32] Cellular Therapy Using Regulatory T Cells in Uveitis
    Terrada, Celine
    Gregoire, Sylvie
    Billiard, Fabienne
    Klatzmann, David
    Lehoang, Phuc
    Bodaghi, Bahram
    Salomon, Benoit
    HUMAN GENE THERAPY, 2009, 20 (06) : 667 - 668
  • [33] T-Regulatory Cells In Tumor Progression And Therapy
    Verma, Amit
    Mathur, Rohit
    Farooque, Abdullah
    Kaul, Vandana
    Gupta, Seema
    Dwarakanath, Bilikere S.
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 10731 - 10747
  • [34] Gene Therapy with Regulatory T Cells: A Beneficial Alliance
    Biswas, Moanaro
    Kumar, Sandeep R. P.
    Terhorst, Cox
    Herzog, Roland W.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [35] Methods to manufacture regulatory T cells for cell therapy
    MacDonald, K. N.
    Piret, J. M.
    Levings, M. K.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2019, 197 (01): : 52 - 63
  • [36] Interaction between regulatory T cells and cancer stem cells
    Yu, Xiaozhou
    Li, Hui
    Ren, Xiubao
    INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (07) : 1491 - 1498
  • [37] Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells
    Oberg, Hans-Heinrich
    Wesch, Daniela
    Kalyan, Shirin
    Kabelitz, Dieter
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [38] The effect of ionizing radiation on regulatory T cells in health and disease
    Persa, Eszter
    Balogh, Andrea
    Safrany, Geza
    Lumniczky, Katalin
    CANCER LETTERS, 2015, 368 (02) : 252 - 261
  • [39] Balancing between immunity and tolerance: An interplay between dendritic cells, regulatory T cells, and effector T cells
    Cools, Nathalie
    Ponsaerts, Peter
    Van Tendeloo, Viggo F. I.
    Berneman, Zwi N.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (06) : 1365 - 1374
  • [40] RELATIONSHIP BETWEEN MICROVASCULAR T REGULATORY LYMPHOCYTES AND CIRCULATING LYMPHOCYTES
    De Ciuceis, C.
    Rossini, C.
    Airo, P.
    Scarsi, M.
    Tincani, A.
    Merigo, G.
    Porteri, E.
    Petroboni, B.
    Gavazzi, A.
    Rosei, C. Agabiti
    Castellano, M.
    Mori, L.
    Sarkar, A.
    La Boria, E.
    Duse, S.
    Semeraro, F.
    Pileri, P.
    Rosei, E. Agabiti
    Rizzoni, D.
    JOURNAL OF HYPERTENSION, 2015, 33 : E368 - E368
12345