共 106 条
Network biology:: Understanding the cell's functional organization
被引:5475
作者:

Barabási, AL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA

Oltvai, ZN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA
机构:
[1] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA
[2] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
基金:
美国国家卫生研究院;
美国国家科学基金会;
关键词:
D O I:
10.1038/nrg1272
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to understand how these molecules and the interactions between them determine the function this enormously complex machinery, both in isolation and when surrounded by other cells. Rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize our view of biology and disease pathologies in the twenty-first century.
引用
收藏
页码:101 / U15
页数:14
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共 106 条
[41]
A protein interaction map of Drosophila melanogaster
[J].
Giot, L
;
Bader, JS
;
Brouwer, C
;
Chaudhuri, A
;
Kuang, B
;
Li, Y
;
Hao, YL
;
Ooi, CE
;
Godwin, B
;
Vitols, E
;
Vijayadamodar, G
;
Pochart, P
;
Machineni, H
;
Welsh, M
;
Kong, Y
;
Zerhusen, B
;
Malcolm, R
;
Varrone, Z
;
Collis, A
;
Minto, M
;
Burgess, S
;
McDaniel, L
;
Stimpson, E
;
Spriggs, F
;
Williams, J
;
Neurath, K
;
Ioime, N
;
Agee, M
;
Voss, E
;
Furtak, K
;
Renzulli, R
;
Aanensen, N
;
Carrolla, S
;
Bickelhaupt, E
;
Lazovatsky, Y
;
DaSilva, A
;
Zhong, J
;
Stanyon, CA
;
Finley, RL
;
White, KP
;
Braverman, M
;
Jarvie, T
;
Gold, S
;
Leach, M
;
Knight, J
;
Shimkets, RA
;
McKenna, MP
;
Chant, J
;
Rothberg, JM
.
SCIENCE,
2003, 302 (5651)
:1727-1736

Giot, L
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Bader, JS
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Brouwer, C
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Chaudhuri, A
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Kuang, B
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Li, Y
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Hao, YL
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Ooi, CE
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Godwin, B
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Vitols, E
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Vijayadamodar, G
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Pochart, P
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Machineni, H
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Welsh, M
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Kong, Y
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Zerhusen, B
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Malcolm, R
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Varrone, Z
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Collis, A
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Minto, M
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Burgess, S
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

McDaniel, L
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Stimpson, E
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Spriggs, F
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Williams, J
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Neurath, K
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Ioime, N
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Agee, M
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Voss, E
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Furtak, K
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Renzulli, R
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Aanensen, N
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Carrolla, S
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Bickelhaupt, E
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Lazovatsky, Y
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

DaSilva, A
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Zhong, J
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Stanyon, CA
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Finley, RL
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

White, KP
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Braverman, M
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Jarvie, T
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Gold, S
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Leach, M
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Knight, J
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Shimkets, RA
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

McKenna, MP
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Chant, J
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA

Rothberg, JM
论文数: 0 引用数: 0
h-index: 0
机构: GuraGen Corp, New Haven, CT 06511 USA
[42]
Community structure in social and biological networks
[J].
Girvan, M
;
Newman, MEJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (12)
:7821-7826

Girvan, M
论文数: 0 引用数: 0
h-index: 0
机构: Santa Fe Inst, Santa Fe, NM 87501 USA

Newman, MEJ
论文数: 0 引用数: 0
h-index: 0
机构: Santa Fe Inst, Santa Fe, NM 87501 USA
[43]
Fluctuation-driven dynamics of the Internet topology
[J].
Goh, KI
;
Kahng, B
;
Kim, D
.
PHYSICAL REVIEW LETTERS,
2002, 88 (10)
:4-108701

Goh, KI
论文数: 0 引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Sch Phys, Seoul 151747, South Korea Seoul Natl Univ, Sch Phys, Seoul 151747, South Korea

Kahng, B
论文数: 0 引用数: 0
h-index: 0
机构: Seoul Natl Univ, Sch Phys, Seoul 151747, South Korea

Kim, D
论文数: 0 引用数: 0
h-index: 0
机构: Seoul Natl Univ, Sch Phys, Seoul 151747, South Korea
[44]
A relationship between gene expression and protein interactions on the proteome scale:: analysis of the bacteriophage T7 and the yeast Saccharomyces cerevisiae
[J].
Grigoriev, A
.
NUCLEIC ACIDS RESEARCH,
2001, 29 (17)
:3513-3519

Grigoriev, A
论文数: 0 引用数: 0
h-index: 0
机构:
GPC Biotech, D-82152 Martinsried, Germany GPC Biotech, D-82152 Martinsried, Germany
[45]
From molecular to modular cell biology
[J].
Hartwell, LH
;
Hopfield, JJ
;
Leibler, S
;
Murray, AW
.
NATURE,
1999, 402 (6761)
:C47-C52

Hartwell, LH
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

Hopfield, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

Leibler, S
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

Murray, AW
论文数: 0 引用数: 0
h-index: 0
机构: Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[46]
Engineered gene circuits
[J].
Hasty, J
;
McMillen, D
;
Collins, JJ
.
NATURE,
2002, 420 (6912)
:224-230

Hasty, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

McMillen, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

Collins, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[47]
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution
[J].
Hinman, VF
;
Nguyen, AT
;
Cameron, RA
;
Davidson, EH
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (23)
:13356-13361

Hinman, VF
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Div Biol, Pasadena, CA 91125 USA

Nguyen, AT
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Div Biol, Pasadena, CA 91125 USA

Cameron, RA
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Div Biol, Pasadena, CA 91125 USA

Davidson, EH
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Div Biol, Pasadena, CA 91125 USA
[48]
Subnetwork hierarchies of biochemical pathways
[J].
Holme, P
;
Huss, M
;
Jeong, HW
.
BIOINFORMATICS,
2003, 19 (04)
:532-538

Holme, P
论文数: 0 引用数: 0
h-index: 0
机构:
Umea Univ, Dept Theoret Phys, S-90187 Umea, Sweden Umea Univ, Dept Theoret Phys, S-90187 Umea, Sweden

Huss, M
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ, Dept Theoret Phys, S-90187 Umea, Sweden

Jeong, HW
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ, Dept Theoret Phys, S-90187 Umea, Sweden
[49]
Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
[J].
Ibarra, RU
;
Edwards, JS
;
Palsson, BO
.
NATURE,
2002, 420 (6912)
:186-189

Ibarra, RU
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

Edwards, JS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

Palsson, BO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[50]
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
[J].
Ideker, T
;
Thorsson, V
;
Ranish, JA
;
Christmas, R
;
Buhler, J
;
Eng, JK
;
Bumgarner, R
;
Goodlett, DR
;
Aebersold, R
;
Hood, L
.
SCIENCE,
2001, 292 (5518)
:929-934

Ideker, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Thorsson, V
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Ranish, JA
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Christmas, R
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Buhler, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Eng, JK
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

论文数: 引用数:
h-index:
机构:

Goodlett, DR
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Aebersold, R
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA

Hood, L
论文数: 0 引用数: 0
h-index: 0
机构: Inst Syst Biol, Seattle, WA 98105 USA
