Network biology:: Understanding the cell's functional organization

被引:5475
作者
Barabási, AL
Oltvai, ZN
机构
[1] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA
[2] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1038/nrg1272
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to understand how these molecules and the interactions between them determine the function this enormously complex machinery, both in isolation and when surrounded by other cells. Rapid advances in network biology indicate that cellular networks are governed by universal laws and offer a new conceptual framework that could potentially revolutionize our view of biology and disease pathologies in the twenty-first century.
引用
收藏
页码:101 / U15
页数:14
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