Cooperativity in macromolecular assembly

被引：100
|
作者：
Williamson, James R. [1 ,2 ]
机构：
[1] Scripps Res Inst, Dept Mol Biol & Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 08期
关键词：
D O I：
10.1038/nchembio.102
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The thermodynamic principle of cooperativity is used to drive the formation of specific macromolecular complexes during the assembly of a macromolecular machine. Understanding cooperativity provides insight into the mechanisms that govern assembly and disassembly of multicomponent complexes. Our understanding of assembly mechanisms is lagging considerably behind our understanding of the structure and function of these complexes. A significant challenge remains in tackling the thermodynamics and kinetics of the intermolecular interactions required for all cellular functions.
引用
收藏
页码：458 / 465
页数：8
相关论文
共 50 条
  • [41] MACROMOLECULAR INTERACTIONS IN THE ASSEMBLY OF HIV AND OTHER RETROVIRUSES
    HUNTER, E
    SEMINARS IN VIROLOGY, 1994, 5 (01): : 71 - 83
  • [42] MACROMOLECULAR SELF-ASSEMBLY OF DIKETOPIPERAZINE TETRAPEPTIDES
    BERGERON, RJ
    PHANSTIEL, O
    YAO, GW
    MILSTEIN, S
    WEIMAR, WR
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (19) : 8479 - 8484
  • [43] Intracellular Galectins: Platforms for Assembly of Macromolecular Complexes
    Wang, John L.
    Haudek, Kevin C.
    Voss, Patricia G.
    Patterson, Ronald J.
    Arnoys, Eric J.
    GALECTINS AND DISEASE IMPLICATIONS FOR TARGETED THERAPEUTICS, 2012, 1115 : 81 - +
  • [44] Macromolecular assembly: Chainmail stabilization of a viral capsid
    Johnson, JE
    Wikoff, WR
    CURRENT BIOLOGY, 1998, 8 (25) : R914 - R917
  • [45] Molecular simulations of conformational dynamics of macromolecular assembly
    Li, GH
    Cui, Q
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 360A - 360A
  • [46] Macromolecular self-assembly and nanotechnology in China
    Xu, Huaping
    Chen, Daoyong
    Wang, Shu
    Zhou, Yongfeng
    Sun, Junqi
    Zhang, Wenke
    Zhang, Xi
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2013, 371 (2000):
  • [47] Macromolecular Structure Assembly as a Novel Antibiotic Target
    Champney, Scott
    ANTIBIOTICS-BASEL, 2022, 11 (07):
  • [48] Anion transport through macromolecular polycation assembly
    Coughlin, E. Bryan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [49] MACROMOLECULAR ASSEMBLY - A HIERARCHICAL ENTITY IN CELLULAR ORGANIZATION
    SCHMITT, FO
    DEVELOPMENTAL BIOLOGY, 1963, 7 (01) : 546 - &
  • [50] Macromolecular self-assembly from carbohydrates
    Chen, Guosong
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
12345