Cooperativity in macromolecular assembly

被引：100
|
作者：
Williamson, James R. [1 ,2 ]
机构：
[1] Scripps Res Inst, Dept Mol Biol & Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 08期
关键词：
D O I：
10.1038/nchembio.102
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The thermodynamic principle of cooperativity is used to drive the formation of specific macromolecular complexes during the assembly of a macromolecular machine. Understanding cooperativity provides insight into the mechanisms that govern assembly and disassembly of multicomponent complexes. Our understanding of assembly mechanisms is lagging considerably behind our understanding of the structure and function of these complexes. A significant challenge remains in tackling the thermodynamics and kinetics of the intermolecular interactions required for all cellular functions.
引用
收藏
页码：458 / 465
页数：8
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