Influence of the reaction conditions in the N-alkylation of acridone-2-carboxylic acids

被引：0
|
作者：
Marill, LX [1 ]
Comdom, RFP [1 ]
Hermández, MM [1 ]
机构：
[1] Ctr Pharmaceut Chem, Havana, Cuba
来源：
SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 14期
关键词：
D O I：
10.1081/SCC-100104467
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis and a study about the influence of the solvent in the alkylation reaction of 2-Carboxy-6-chloro-9(10H) acridone (3b) and 2-Carboxy-6-chloro-7-nitro-9(10H) acridone (3a) was done, obtaining the N-ethyl ester derivative of the alkylated products. Using the liquid-liquid phase transfer catalysis only the N-alkylated derivative was obtained in both cases with an improved yield.
引用
收藏
页码：2159 / 2167
页数：9
相关论文
共 50 条
  • [41] N-Alkylation Reaction in the Synthesis of Tetra-Substituted Glycoluryls
    Sinitsyna, Anastasia A.
    Il'yasov, Sergey G.
    JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY, 2020, 13 (01): : 40 - 45
  • [42] NEW N-ALKYLATION REACTION .5. NMR INVESTIGATIONS
    SOHAR, P
    TOLDY, L
    REITER, J
    OMR-ORGANIC MAGNETIC RESONANCE, 1971, 3 (06): : 689 - &
  • [43] N-ALKYLATION OF PYRIDYLALANINE AND PYRIDINECARBOXYLIC ACIDS AND THEIR USE IN SYNTHESIS OF GNRH ANTAGONISTS
    ZHANG, YL
    TIAN, ZP
    KOWALCZUK, M
    EDWARDS, P
    ROESKE, RW
    TETRAHEDRON LETTERS, 1993, 34 (23) : 3659 - 3662
  • [44] N-alkylation of indole compounds in modified Wittig-Horner reaction
    Singh, Anil K.
    Asefa, Abera
    SYNTHETIC COMMUNICATIONS, 2007, 37 (7-9) : 1491 - 1494
  • [45] N-ALKYLATION OF 2- AND 4-CARBAMOYLPYRIDINE
    HJEDS, H
    ACTA CHEMICA SCANDINAVICA, 1963, 17 (08): : 2351 - +
  • [46] N-ALKYLATION OF SULFILIMINES AND SULFOXIMINES (1,2)
    JOHNSON, CR
    RIGAU, JJ
    HAAKE, M
    MCCANTS, D
    KEISER, JE
    GERTSEMA, A
    TETRAHEDRON LETTERS, 1968, (34) : 3719 - &
  • [47] N-ALKYLATION OF IMIDES WITH O-ALKYLISOUREA UNDER NEUTRAL CONDITIONS
    INOUE, Y
    TAGUCHI, M
    HASHIMOTO, H
    SYNTHESIS-STUTTGART, 1986, (04): : 332 - 334
  • [48] A convenient selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid
    Edmont, D
    Chenault, J
    SYNLETT, 2001, (06) : 833 - 835
  • [49] N-ALKYLATION OF PHENOBARBITAL UNDER PHASE-TRANSFER CATALYSIS CONDITIONS
    DEPREUX, P
    BETHEGNIES, G
    SYNTHETIC COMMUNICATIONS, 1993, 23 (08) : 1189 - 1193
  • [50] N-Alkylation of α-Iminophosphonates and Application to Horner-Wadsworth-Emmons Reaction
    Shimizu, Makoto
    Tateishi, Masasato
    Mizota, Isao
    CHEMISTRY LETTERS, 2014, 43 (11) : 1752 - 1754
12345