Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells

被引:0
|
作者
Lamarche, C. [1 ]
Mackall, C. [2 ]
Weber, E. [2 ]
Levings, M. [3 ,4 ]
机构
[1] Univ British Columbia, Vancouver, BC, Canada
[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[3] Univ British Columbia, Surg, Vancouver, BC, Canada
[4] BC Childrens Hosp Res Inst, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
535
引用
收藏
页码:331 / 332
页数:2
相关论文
共 50 条
  • [41] Grafting chimeric antigen receptors to redirect T cells Carving the CAR
    Riddell, S. R.
    Protzer, U.
    GENE THERAPY, 2010, 17 (10) : 1191 - 1192
  • [42] Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy
    Dai, Hanren
    Wang, Yao
    Lu, Xuechun
    Han, Weidong
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (07):
  • [43] Chimeric antigen receptors interact with multiple endogenous T cell proteins and induce tonic signaling through phosphorylation of endogenous CD3ζ
    Ramello, Maria C.
    Benzaid, Ismahene
    Kuenzi, Brent M.
    Lienlaf, Maritza
    Kandell, Wendy M.
    Santiago, Daniel N.
    Pabon-Saldana, Mibel
    Darville, Lancia
    Fang, Bin
    Rix, Uwe
    Yoder, Sean
    Berglund, Anders
    Koomen, John
    Haura, Eric
    Abate-Daga, Daniel
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [44] Genetic Modification of T Cells with Chimeric Antigen Receptors: A Laboratory Manual
    Golumba-Nagy, Viktoria
    Kuehle, Johannes
    Abken, Hinrich
    HUMAN GENE THERAPY METHODS, 2017, 28 (06) : 302 - 309
  • [45] Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling
    Landoni, Elisa
    Fuca, Giovanni
    Wang, Jian
    Chirasani, Venkat R.
    Yao, Zhiyuan
    Dukhovlinova, Elena
    Ferrone, Soldano
    Savoldo, Barbara
    Hong, Lee K.
    Shou, Peishun
    Musio, Silvia
    Padelli, Francesco
    Finocchiaro, Gaetano
    Droste, Miriam
    Kuhlman, Brian
    Shamshiev, Abdijapar
    Pellegatta, Serena
    Dokholyan, Nikolay, V
    Dotti, Gianpietro
    CANCER IMMUNOLOGY RESEARCH, 2021, 9 (04) : 441 - 453
  • [46] A Direct Comparison of the In Vivo Efficacy and in Vitro Signaling of Chimeric Antigen Receptors and Endogenous T Cell Receptors
    Kohler, Mark Eric
    Yang, Yinmeng
    Sepulveda, Gian
    Fry, Terry J.
    BLOOD, 2017, 130
  • [47] Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors
    Karlsson, Hannah
    Svensson, Emma
    Gigg, Camilla
    Jarvius, Malin
    Olsson-Stromberg, Ulla
    Savoldo, Barbara
    Dotti, Gianpietro
    Loskog, Angelica
    PLOS ONE, 2015, 10 (12):
  • [48] Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
    MacDonald, Katherine G.
    Hoeppli, Romy E.
    Huang, Qing
    Gillies, Jana
    Luciani, Dan S.
    Orban, Paul C.
    Broady, Raewyn
    Levings, Megan K.
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (04): : 1413 - 1424
  • [49] MYELOID CELLS DRIVE IMMUNOSUPPRESSION OF CHIMERIC ANTIGEN RECEPTOR T CELLS IN THE NEURONAL MICROENVIRONMENT OF GLIOBLASTOMA
    Zhang, J.
    Ehr, J., V
    Look, T.
    Benotmane, J. K.
    Neidert, N.
    Kueckelhaus, J.
    Weiss, T.
    Heiland, D. H.
    Yabo, Y. A.
    NEURO-ONCOLOGY, 2024, 26 : V28 - V28
  • [50] Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy
    Dongdong Ti
    Yunfei Niu
    Zhiqiang Wu
    Xiaobing Fu
    Weidong Han
    Science China(Life Sciences), 2018, (11) : 1320 - 1332