Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells

被引:0
|
作者
Lamarche, C. [1 ]
Mackall, C. [2 ]
Weber, E. [2 ]
Levings, M. [3 ,4 ]
机构
[1] Univ British Columbia, Vancouver, BC, Canada
[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[3] Univ British Columbia, Surg, Vancouver, BC, Canada
[4] BC Childrens Hosp Res Inst, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
535
引用
收藏
页码:331 / 332
页数:2
相关论文
共 50 条
  • [31] Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    A Loskog
    V Giandomenico
    C Rossig
    M Pule
    G Dotti
    M K Brenner
    Leukemia, 2006, 20 : 1819 - 1828
  • [32] Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    Loskog, A.
    Giandomenico, V.
    Rossig, C.
    Pule, M.
    Dotti, G.
    Brenner, M. K.
    LEUKEMIA, 2006, 20 (10) : 1819 - 1828
  • [33] Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs
    Balagopalan, Lakshmi
    Moreno, Taylor
    Qin, Haiying
    Angeles, Benjamin C.
    Kondo, Taisuke
    Yi, Jason
    McIntire, Katherine M.
    Alvinez, Neriah
    Pallikkuth, Sandeep
    Lee, Mariah E.
    Yamane, Hidehiro
    Tran, Andy D.
    Youkharibache, Philippe
    Cachau, Raul E.
    Taylor, Naomi
    Samelson, Lawrence E.
    SCIENCE SIGNALING, 2024, 17 (846)
  • [34] Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression
    Pohl, Alessandra De Paula
    Schmidt, Anja
    Zhang, Ai-Hong
    Maldonado, Tania
    Koenigs, Christoph
    Scott, David W.
    CELLULAR IMMUNOLOGY, 2020, 358
  • [35] Effects of Chimeric Antigen Receptor (CAR) Expression on Regulatory T Cells
    Akalin, Ibrahim
    Perna, Serena K.
    De Angelis, Biagio
    Okur, Fatma V.
    Rooney, Cliona M.
    Heslop, Helen
    Brenner, Malcolm K.
    Savoldo, Barbara
    Dotti, Gianpietro
    MOLECULAR THERAPY, 2009, 17 : S25 - S25
  • [36] Repurposing chimeric antigen receptor regulatory T cells for treating cancer
    Ferreira, Leonardo M.
    Cochrane, Russell W.
    Robino, Rob A.
    Granger, Bryan
    Allen, Eva
    Gudivada, Vishnu
    de Cubas, Aguirre A.
    Berto, Stefano
    CANCER RESEARCH, 2024, 84 (07)
  • [37] Impact of regulatory T cells on antigen specific T cell response using recombinant chimeric T cell receptors in vivo.
    Kofler, David M.
    Chmielewski, Markus
    Koehler, Heike
    Riet, Tobias
    Schmidt, Patrick
    Rappl, Gunter
    Hombach, Andreas
    Hallek, Michael
    Wendtner, Clemens M.
    Abken, Hinrich
    BLOOD, 2006, 108 (11) : 465B - 465B
  • [38] Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells
    Dawson, Nicholas A. J.
    Rosado-Sanchez, Isaac
    Novakovsky, German E.
    Fung, Vivian C. W.
    Huang, Qing
    McIver, Emma
    Sun, Grace
    Gillies, Jana
    Speck, Madeleine
    Orban, Paul C.
    Mojibian, Majid
    Levings, Megan K.
    SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (557)
  • [39] High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells
    Cochrane, Russell W.
    Robino, Rob A.
    Granger, Bryan
    Allen, Eva
    Vaena, Silvia
    Romeo, Martin J.
    de Cubas, Aguirre A.
    Berto, Stefano
    Ferreira, Leonardo M. R.
    MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2024, 32 (04)
  • [40] Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?
    Boardman, Dominic
    Maher, John
    Lechler, Robert
    Smyth, Lesley
    Lombardi, Giovanna
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2016, 44 : 342 - 348