Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications

被引:10
|
作者
Xu, Zhanyan [1 ]
Omar, Abdalla M. [1 ]
Bartolo, Paulo [1 ]
机构
[1] Univ Manchester, Sch Mech Aerosp & Civil Engn, Manchester M13 9PL, England
基金
英国工程与自然科学研究理事会;
关键词
additive manufacturing; bone scaffolds; finite element analysis; mechanical analysis;
D O I
10.3390/ma14133546
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds.
引用
收藏
页数:11
相关论文
共 50 条
  • [41] 3D-printed scaffolds with calcified layer for osteochondral tissue engineering
    Li, Zhengyu
    Jia, Shuaijun
    Xiong, Zhuo
    Long, Qianfa
    Yan, Shaorong
    Hao, Fu
    Liu, Jian
    Yuan, Zhi
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2018, 126 (03) : 389 - 396
  • [42] In silico simulations of diffusion tensors and tortuosity in cells grown on 3D-printed scaffolds for tissue engineering
    Cartlidge, Topaz A. A.
    Wu, Yan
    Robertson, Thomas B. R.
    Katsamenis, Orestis L.
    Pileio, Giuseppe
    RSC ADVANCES, 2024, 14 (44) : 32398 - 32410
  • [43] 3D-Printed Demineralized Bone Matrix-Based Conductive Scaffolds Combined with Electrical Stimulation for Bone Tissue Engineering Applications
    Dixon, Damion T.
    Landree, Erika N.
    Gomillion, Cheryl T.
    ACS APPLIED BIO MATERIALS, 2024, : 4366 - 4378
  • [44] The Effect of Spironolactone Loading on the Properties of 3D-Printed Polycaprolactone/Gold Nanoparticles Composite Scaffolds for Myocardial Tissue Engineering
    Ghaziof, Sharareh
    Shojaei, Shahrokh
    Mehdikhani, Mehdi
    Khodaei, Mohammad
    Nodoushan, Milad Jafari
    JOURNAL OF BIONIC ENGINEERING, 2024, 21 (02) : 924 - 937
  • [45] The Effect of Spironolactone Loading on the Properties of 3D-Printed Polycaprolactone/Gold Nanoparticles Composite Scaffolds for Myocardial Tissue Engineering
    Sharareh Ghaziof
    Shahrokh Shojaei
    Mehdi Mehdikhani
    Mohammad Khodaei
    Milad Jafari Nodoushan
    Journal of Bionic Engineering, 2024, 21 : 924 - 937
  • [46] 3D-printed polycaprolactone-magnetic nanoparticles composite multifunctional scaffolds for bone tissue regeneration and hyperthermia treatment
    Kanwar, Susheem
    Vijayavenkataraman, Sanjairaj
    INTERNATIONAL JOURNAL OF BIOPRINTING, 2024, 10 (06) : 391 - 406
  • [47] Biomimetic mineralization of 3D-printed polyhydroxyalkanoate-based microbial scaffolds for bone tissue engineering
    Kim, Dahong
    Lee, Su Jeong
    Lee, DongJin
    Seok, Ji Min
    Yeo, Seon Ju
    Lim, Hyungjun
    Lee, Jae Jong
    Song, Jae Hwang
    Lee, Kangwon
    Park, Won Ho
    Park, Su A.
    INTERNATIONAL JOURNAL OF BIOPRINTING, 2024, 10 (02) : 489 - 499
  • [48] Hydrogel-integrated 3D-printed poly(lactic acid) scaffolds for bone tissue engineering
    Das, Mitun
    Sharabani-Yosef, Orna
    Eliaz, Noam
    Mandler, Daniel
    JOURNAL OF MATERIALS RESEARCH, 2021, 36 (19) : 3833 - 3842
  • [49] Bioactive 3D-printed chitosan-based scaffolds for personalized craniofacial bone tissue engineering
    Yousefiasl S.
    Sharifi E.
    Salahinejad E.
    Makvandi P.
    Irani S.
    Engineered Regeneration, 2023, 4 (01): : 1 - 11
  • [50] Oxygen Plasma Treatment on 3D-Printed Chitosan/Gelatin/Hydroxyapatite Scaffolds for Bone Tissue Engineering
    Lee, Chang-Min
    Yang, Seong-Won
    Jung, Sang-Chul
    Kim, Byung-Hoon
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2017, 17 (04) : 2747 - 2750