Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications

被引:10
|
作者
Xu, Zhanyan [1 ]
Omar, Abdalla M. [1 ]
Bartolo, Paulo [1 ]
机构
[1] Univ Manchester, Sch Mech Aerosp & Civil Engn, Manchester M13 9PL, England
基金
英国工程与自然科学研究理事会;
关键词
additive manufacturing; bone scaffolds; finite element analysis; mechanical analysis;
D O I
10.3390/ma14133546
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds.
引用
收藏
页数:11
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