Male contraceptive development: A medicinal chemistry perspective

被引：6

作者：

Norcross, Neil R. ^{[1
]}

Georgiou, Irene ^{[1
]}

Johnston, Zoe C. ^{[2
]}

Gruber, Franz S. ^{[3
]}

Swedlow, Jason R. ^{[3
]}

Read, Kevin D. ^{[1
]}

Barratt, Christopher LR. ^{[2
]}

Gilbert, Ian H. ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Biol Chem & Drug Discovery, Drug Discovery Unit, Dundee DD1 5EH, Angus, Scotland

[2] Univ Dundee, Ninewells Hosp & Med Sch, Sch Med, Dundee DD19SY, Angus, Scotland

[3] Univ Dundee, Ctr Gene Regulat & Express, Natl Phenotyp Screening Ctr, Sch Life Sci, Dundee DD1, Angus, Scotland

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 243卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

RETINOIC ACID; MALE-FERTILITY; ALDEHYDE DEHYDROGENASE; DRUG DISCOVERY; IN-VITRO; SPERM; INHIBITORS; TESTIS; SPERMATOGENESIS; INFERTILITY;

D O I：

10.1016/j.ejmech.2022.114709

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is un-derstood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

引用

页数：8

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