Male contraceptive development: A medicinal chemistry perspective

被引：6

作者：

Norcross, Neil R. ^{[1
]}

Georgiou, Irene ^{[1
]}

Johnston, Zoe C. ^{[2
]}

Gruber, Franz S. ^{[3
]}

Swedlow, Jason R. ^{[3
]}

Read, Kevin D. ^{[1
]}

Barratt, Christopher LR. ^{[2
]}

Gilbert, Ian H. ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Biol Chem & Drug Discovery, Drug Discovery Unit, Dundee DD1 5EH, Angus, Scotland

[2] Univ Dundee, Ninewells Hosp & Med Sch, Sch Med, Dundee DD19SY, Angus, Scotland

[3] Univ Dundee, Ctr Gene Regulat & Express, Natl Phenotyp Screening Ctr, Sch Life Sci, Dundee DD1, Angus, Scotland

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 243卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

RETINOIC ACID; MALE-FERTILITY; ALDEHYDE DEHYDROGENASE; DRUG DISCOVERY; IN-VITRO; SPERM; INHIBITORS; TESTIS; SPERMATOGENESIS; INFERTILITY;

D O I：

10.1016/j.ejmech.2022.114709

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is un-derstood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

引用

页数：8

共 50 条

[31] GNRH ANTAGONISTS IN MEN - DEVELOPMENT OF A MALE CONTRACEPTIVE
PAVLOU, SN
CONTRACEPTION, 1992, 46 (02) : 197 - 197
[32] Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective
Chang, Xiujin
Qu, Fangui
Li, Chunxiao
Zhang, Jingtian
Zhang, Yanqing
Xie, Yuanyuan
Fan, Zhongpeng
Bian, Jinlei
Wang, Jubo
Li, Zhiyu
Xu, Xi
MEDICINAL RESEARCH REVIEWS, 2024, 44 (04) : 1727 - 1767
[33] Recent Advances in the Development of Dopamine D3 Receptor Antagonists: a Medicinal Chemistry Perspective
Micheli, Fabrizio
CHEMMEDCHEM, 2011, 6 (07) : 1152 - 1162
[34] Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective
Arora, Meghna
Singh, Ankit Kumar
Kumar, Adarsh
Singh, Harshwardhan
Pathak, Prateek
Grishina, Maria
Yadav, Jagat Pal
Verma, Amita
Kumar, Pradeep
RSC MEDICINAL CHEMISTRY, 2024, 15 (10): : 3345 - 3370
[35] Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts
Parrill, Abby L.
Baker, Daniel L.
EXPERT OPINION ON THERAPEUTIC PATENTS, 2010, 20 (12) : 1619 - 1625
[36] Designing of kinase hinge binders: A medicinal chemistry perspective
Sharma, Vikas
Gupta, Mohit
CHEMICAL BIOLOGY & DRUG DESIGN, 2022, 100 (06) : 968 - 980
[37] Molecular drug targets for scabies: a medicinal chemistry perspective
Inam, Wali
Walton, Shelley
Khan, Sheraz
Mahmood, Wajahat
FUTURE MEDICINAL CHEMISTRY, 2020, 12 (24) : 2225 - 2238
[38] Subtleties in GPCR drug discovery: a medicinal chemistry perspective
Fujioka, Masahiko
Omori, Naoki
DRUG DISCOVERY TODAY, 2012, 17 (19-20) : 1133 - 1138
[39] Migraine and Its Treatment from the Medicinal Chemistry Perspective
Pehlivanlar, Ezgi
Carradori, Simone
Simsek, Rahime
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2024, 7 (04) : 951 - 966
[40] Apoptosis based therapies from a medicinal chemistry perspective
Pellecchia, Maurizio
MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3623S - 3623S

← 1 2 3 4 5 →