Rh(III)-Catalyzed Oxidative Annulation Leading to Substituted Indolizines by Cleavage of C(sp2)-H/C(sp3)-H Bonds

被引：68

作者：

Shen, Bingxue ^{[1
]}

Li, Bin ^{[1
]}

Wang, Baiquan ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 12期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; PYRROLE-CONTAINING HETEROCYCLES; HIGHLY EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; PYRIDINIUM YLIDES; DIAZO-COMPOUNDS; CATALYZED CYCLOISOMERIZATION; FUNCTIONALIZED INDOLIZINES; INTERMOLECULAR AMIDATION; ROOM-TEMPERATURE;

D O I：

10.1021/acs.orglett.6b01181

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(III)-catalyzed oxidative annulation reactions of pyridinium trifluoromethanesulfonate salts with alkynes leading to substituted indolizines by cleavage of C(sp(2))-H/C(sp(3))-H bonds are developed. The starting materials are readily available, and the reactions have a broad substrate scope. This reaction overcomes some drawbacks of the previous indolizine synthetic methods and provides a new efficient route to indolizine derivatives.

引用

页码：2816 / 2819

页数：4

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