Rh(III)-Catalyzed Oxidative Annulation Leading to Substituted Indolizines by Cleavage of C(sp2)-H/C(sp3)-H Bonds

被引：68
|
作者：
Shen, Bingxue [1 ]
Li, Bin [1 ]
Wang, Baiquan [1 ,2 ,3 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 12期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; PYRROLE-CONTAINING HETEROCYCLES; HIGHLY EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; PYRIDINIUM YLIDES; DIAZO-COMPOUNDS; CATALYZED CYCLOISOMERIZATION; FUNCTIONALIZED INDOLIZINES; INTERMOLECULAR AMIDATION; ROOM-TEMPERATURE;
D O I：
10.1021/acs.orglett.6b01181
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rhodium(III)-catalyzed oxidative annulation reactions of pyridinium trifluoromethanesulfonate salts with alkynes leading to substituted indolizines by cleavage of C(sp(2))-H/C(sp(3))-H bonds are developed. The starting materials are readily available, and the reactions have a broad substrate scope. This reaction overcomes some drawbacks of the previous indolizine synthetic methods and provides a new efficient route to indolizine derivatives.
引用
收藏
页码：2816 / 2819
页数：4
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