GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat
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作者:
Kotmanova, Z.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Kotmanova, Z.
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Simera, M.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Simera, M.
[1
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Veternik, M.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Veternik, M.
[1
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Martvon, L.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Martvon, L.
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Misek, J.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Misek, J.
[1
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Jakus, J.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Jakus, J.
[1
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Shen, T. Y.
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Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USAComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Shen, T. Y.
[2
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Musselwhite, M. N.
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Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USAComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Musselwhite, M. N.
[2
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Pitts, T.
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Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Dept Neurol Surg, Louisville, KY 40292 USAComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Pitts, T.
[3
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Bolser, D. C.
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Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USAComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Bolser, D. C.
[2
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Poliacek, I.
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Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
Poliacek, I.
[1
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机构:
[1] Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
[2] Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA
[3] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Dept Neurol Surg, Louisville, KY 40292 USA
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 +/- 4 nl), 1 mM baclofen (64 +/- 4 nl) and unilateral microinjections of 0.5 mM muscimol (33 1 nl) in the rNTS significantly reduced cough number (CN), amplitudes of ABD EMGs, expiratory EP, and prolonged the duration of the cough inspiratory phase. GABA microinjections decreased the amplitudes of cough-related DIA EMGs and inspiratory EP; muscimol microinjections decreased the cough DIA EMG on the contralateral side. Only microinjections of GABA into the cNTS suppressed CN. In some cases, microinjections prolonged the inspiratory phase, lowered respiratory rate, changed the depth of breathing, and increased blood pressure and heart rate. Our results confirm that GABA-ergic inhibitory mechanisms in the rNTS can regulate coughing in the anesthetized cat.