GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat

被引:12
|
作者
Kotmanova, Z. [1 ]
Simera, M. [1 ]
Veternik, M. [1 ]
Martvon, L. [1 ]
Misek, J. [1 ]
Jakus, J. [1 ]
Shen, T. Y. [2 ]
Musselwhite, M. N. [2 ]
Pitts, T. [3 ]
Bolser, D. C. [2 ]
Poliacek, I. [1 ]
机构
[1] Comenius Univ, Jessenius Fac Med Martin, Inst Med Biophys, Mala Hora 4, Martin 03601, Slovakia
[2] Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA
[3] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Dept Neurol Surg, Louisville, KY 40292 USA
关键词
Muscimol; Baclofen; Microinjection; Airway defense; Cough control; EXCITATORY AMINO-ACIDS; TRACHEOBRONCHIAL COUGH; MEDIATED NEUROTRANSMISSION; RESPIRATORY NEURONS; ANESTHETIZED CATS; SYNAPTIC INPUTS; REFLEX; RECEPTORS; GABA; RAT;
D O I
10.1016/j.resp.2018.02.009
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 +/- 4 nl), 1 mM baclofen (64 +/- 4 nl) and unilateral microinjections of 0.5 mM muscimol (33 1 nl) in the rNTS significantly reduced cough number (CN), amplitudes of ABD EMGs, expiratory EP, and prolonged the duration of the cough inspiratory phase. GABA microinjections decreased the amplitudes of cough-related DIA EMGs and inspiratory EP; muscimol microinjections decreased the cough DIA EMG on the contralateral side. Only microinjections of GABA into the cNTS suppressed CN. In some cases, microinjections prolonged the inspiratory phase, lowered respiratory rate, changed the depth of breathing, and increased blood pressure and heart rate. Our results confirm that GABA-ergic inhibitory mechanisms in the rNTS can regulate coughing in the anesthetized cat.
引用
收藏
页码:100 / 106
页数:7
相关论文
共 50 条
  • [21] Friedreich Ataxia: Failure of GABA-ergic and Glycinergic Synaptic Transmission in the Dentate Nucleus
    Koeppen, Arnulf H.
    Ramirez, R. Liane
    Becker, Alyssa B.
    Feustel, Paul J.
    Mazurkiewicz, Joseph E.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2015, 74 (02): : 166 - 176
  • [22] During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons
    Brown, Adam R.
    Mitchell, Scott J.
    Peden, Dianne R.
    Herd, Murray B.
    Seifi, Mohsen
    Swinny, Jerome D.
    Belelli, Delia
    Lambert, Jeremy J.
    NEUROPHARMACOLOGY, 2016, 103 : 163 - 173
  • [23] INFLUENCE OF GABA-ERGIC SUBSTANCES ON THE EFFECTS OF STIMULATION OF THE CAUDATE-NUCLEUS AND AMPHETAMINE STEREOTYPY IN CATS
    TOLPYSHEV, BA
    FARMAKOLOGIYA I TOKSIKOLOGIYA, 1980, 43 (02): : 140 - 144
  • [24] Regulation of pedunculopontine tegmental neuronal activity and REM sleep: Role of GABA-ergic neurotransmission in the freely moving rat
    Datta, S
    Patterson, EH
    SLEEP, 2002, 25 : A166 - A167
  • [25] Influence of GABA-ergic and glutamatergic transmission in the pedunculopontine tegmental nucleus on hippocampal theta activity.
    Nowacka, A
    Trojniar, W
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 80 - 80
  • [26] GASTRIC AFFERENTS TO THE NUCLEUS OF THE SOLITARY TRACT IN THE CAT
    GWYN, DG
    LESLIE, RA
    HOPKINS, DA
    NEUROSCIENCE LETTERS, 1979, 14 (01) : 13 - 17
  • [27] CHOLINERGIC SYSTEM OF THE FOREBRAIN MODULATES ACTIVITY OF GABA-ERGIC INTERNEURONES REALIZING PRESYNAPTIC CONTROL IN KITTENS NEOCORTEX
    RAEVSKY, VV
    BUDKO, KP
    MARES, P
    ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 1988, 38 (06) : 1068 - 1075
  • [28] Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract
    Vance, Katie M.
    Ribnicky, David M.
    Rogers, Richard C.
    Hermann, Gerlinda E.
    NEUROSCIENCE LETTERS, 2014, 582 : 115 - 119
  • [29] Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract
    Austgen, James R.
    Hermann, Gerlinda E.
    Dantzler, Heather A.
    Rogers, Richard C.
    Kline, David D.
    JOURNAL OF NEUROPHYSIOLOGY, 2011, 106 (04) : 1822 - 1832
  • [30] Distribution of GABA and glycine in the lamb nucleus of the solitary tract
    Sweazey, RD
    BRAIN RESEARCH, 1996, 737 (1-2) : 275 - 286