Probing Medulloblastoma Initiation at the Single-Cell Level

被引：1
|
作者：
Okonechnikov, Konstantin [1 ,2 ,3 ]
Pfister, Stefan M. [1 ,2 ,3 ,4 ]
Kutscher, Lena M. [1 ,2 ,3 ]
机构：
[1] Hopp Childrens Canc Ctr Heidelberg KiTZ, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, Div Pediat Neurooncol, D-69120 Heidelberg, Germany
[3] German Canc Consortium DKTK, D-69120 Heidelberg, Germany
[4] Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, D-69120 Heidelberg, Germany
来源：
TRENDS IN CANCER | 2019年 / 5卷 / 12期
关键词：
MODEL;
D O I：
10.1016/j.trecan.2019.10.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Medulloblastoma is a pediatric brain tumor arising from the developing cerebellum. Despite significant strides in classifying tumor subgroups and identifying underlying genetic mutations, progress in clinical outcomes has been notably slower. About 30% of patients experience relapse after treatment, possibly because of our inability to identify and eliminate the cancer stem cells. Zhang et al. recently investigated these cells in the SHH subgroup of medulloblastoma and identified drugs that may target them.
引用
收藏
页码：759 / 761
页数：4
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