Probing Medulloblastoma Initiation at the Single-Cell Level

被引：1

作者：

Okonechnikov, Konstantin ^{[1
,2
,3
]}

Pfister, Stefan M. ^{[1
,2
,3
,4
]}

Kutscher, Lena M. ^{[1
,2
,3
]}

机构：

[1] Hopp Childrens Canc Ctr Heidelberg KiTZ, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Div Pediat Neurooncol, D-69120 Heidelberg, Germany

[3] German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[4] Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, D-69120 Heidelberg, Germany

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 12期

关键词：

MODEL;

D O I：

10.1016/j.trecan.2019.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloblastoma is a pediatric brain tumor arising from the developing cerebellum. Despite significant strides in classifying tumor subgroups and identifying underlying genetic mutations, progress in clinical outcomes has been notably slower. About 30% of patients experience relapse after treatment, possibly because of our inability to identify and eliminate the cancer stem cells. Zhang et al. recently investigated these cells in the SHH subgroup of medulloblastoma and identified drugs that may target them.

引用

页码：759 / 761

页数：4

共 50 条

[21] Probing clonal dynamics with single-cell genomics
Julia Simundza
Nature Cancer, 2021, 2 : 1289 - 1289
[22] Probing Cancer Metastasis at a Single-Cell Level with a Raman-Functionalized Anionic Probe
Dharmalingam, Priya
Venkatakrishnan, Krishnan
Tan, Bo
NANO LETTERS, 2020, 20 (02) : 1054 - 1066
[23] Connectomics at the single-cell level
Nina Vogt
Nature Methods, 2017, 14 : 335 - 335
[24] Probing single-cell mechanics with picosecond ultrasonics
Dehoux, Thomas
Ghanem, Maroun Abi
Zouani, Omar F.
Ducousso, Mathieu
Chigarev, Nikolay
Rossignol, Clement
Tsapis, Nicolas
Durrieu, Marie-Christine
Audoin, Bertrand
ULTRASONICS, 2015, 56 : 160 - 171
[25] Probing molecular cell event dynamics at the single-cell level with targeted plasmonic gold nanoparticles: A review
Austin, Lauren A.
Kang, Bin
El-Sayed, Mostafa A.
NANO TODAY, 2015, 10 (05) : 542 - 558
[26] Endothelial cell plasticity at the single-cell level
Alessandra Pasut
Lisa M. Becker
Anne Cuypers
Peter Carmeliet
Angiogenesis, 2021, 24 : 311 - 326
[27] Endothelial cell plasticity at the single-cell level
Pasut, Alessandra
Becker, Lisa M.
Cuypers, Anne
Carmeliet, Peter
ANGIOGENESIS, 2021, 24 (02) : 311 - 326
[28] T Cell Fate at the Single-Cell Level
Buchholz, Veit R.
Schumacher, Ton N. M.
Busch, Dirk H.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34, 2016, 34 : 65 - 92
[29] Mapping Cell Atlases at the Single-Cell Level
Ye, Fang
Wang, Jingjing
Li, Jiaqi
Mei, Yuqing
Guo, Guoji
ADVANCED SCIENCE, 2024, 11 (08)
[30] Single-cell profiling approaches to probing tumor heterogeneity
Khoo, Bee Luan
Chaudhuri, Parthiv Kant
Ramalingam, Naveen
Tan, Daniel Shao Weng
Lim, Chwee Teck
Warkiani, Majid Ebrahimi
INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (02) : 243 - 255

← 1 2 3 4 5 →