Enantio- and Diastereoselective Synthesis of syn-β-Hydroxyallylsilanes via a Chiral (Z)-γ-Silylailylboronate

被引：27
|
作者：
Lira, Ricardo [1 ]
Roush, William R. [1 ]
机构：
[1] Scripps Florida, Dept Chem, Jupiter, FL 33458 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 21期
关键词：
D O I：
10.1021/ol7018746
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
syn-beta-Hydroxyallylsilanes of general structure 11 and 28 are prepared in 50-86% yield and 91-95% ee (for aliphatic aldehydes; 50% ee for benzaldehyde) via the BF(3)center dot Et(2)O-promoted gamma-silylallylboration reactions, using reagents 14 and 15.
引用
收藏
页码：4315 / 4318
页数：4
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