Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes

被引：22

作者：

Zanias, Stergios ^{[2
]}

Papaefstathiou, Giannis S. ^{[3
]}

Raptopoulou, Catherine P. ^{[4
]}

Papazisis, Konstantinos T. ^{[5
]}

Vala, Vasiliki ^{[5
]}

Zambouli, Dimitra ^{[5
]}

Kortsaris, Alexandros H. ^{[5
]}

Kyriakidis, Dimitrios A. ^{[1
,6
]}

Zafiropoulos, Theodoros F. ^{[2
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece

[2] Univ Patras, Dept Chem, Patras 26504, Greece

[3] Natl & Kapodistrian Univ Athens, Dept Chem, Inorgan Chem Lab, Panepistimiopolis 15771, Zografou, Greece

[4] NCSR Demokritos, Inst Mat Sci, Aghia Paraskevi 15310, Greece

[5] Theagenion Krankenhauses, Thessaloniki 54007, Greece

[6] Natl Hellen Res Fdn, Athens 11635, Greece

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2010年 / 2010卷

关键词：

CRYSTAL-STRUCTURE; CELL-LINE; IN-VITRO; ANTITUMOR; CHEMISTRY; BINDING; LIGAND;

D O I：

10.1155/2010/168030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr3 or GaCl3 resulted in the mononuclear complexes [ GaBr3(btaH) 2] (1) and [ GaCl3(btd) 2] (2), respectively, while treatment of GaCl3 with L resulted in the anionic complex (LH)(2)[GaCl4] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

引用

页数：10

共 50 条

[31] Structure - activity relationships of 2-quinolinecarboxaldehyde thiosemicarbazone gallium(III) complexes with potent and selective anticancer activity
Cao, Wanbao
Qi, Jinxu
Qian, Kun
Tian, Liang
Cheng, Zhen
Wang, Yihong
JOURNAL OF INORGANIC BIOCHEMISTRY, 2019, 191 : 174 - 182
[32] Ruthenium Carbonyl Complexes with Azole Heterocycles - Synthesis, X-ray Diffraction Structures, DFT Calculations, Solution Behavior, and Antiproliferative Activity
Kuhn, Paul-Steffen
Meier, Samuel M.
Jovanovic, Katarina K.
Sandler, Isolde
Freitag, Leon
Novitchi, Ghenadie
Gonzalez, Leticia
Radulovic, Sinisa
Arion, Vladimir B.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2016, (10) : 1566 - 1576
[33] Diorganotin Complexes of a Thiosemicarbazone, Synthesis: Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes
Wiecek, Joanna
Kovala-Demertzi, Dimitra
Ciunik, Zbigniew
Zervou, Maria
Demertzis, Mavroudis A.
BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2010, 2010
[34] Synthesis, structure, and in vitro antiproliferative activity of cyclic hypervalent organobismuth(III) chlorides and their triphenylgermylpropionate derivatives
Zhang, Xiao-Wen
Xia, Jun
Yan, Hui-Wen
Luo, Sheng-Lian
Yin, Shuang-Feng
Au, Chak-Tong
Wong, Wai-Yeung
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (18) : 3019 - 3026
[35] SYNTHESIS AND INFRARED STUDIES OF METHYLGALLIUM(III) AND GALLIUM(III) COMPLEXES WITH TRIDENTATE LIGANDS
PELLERITO, L
CEFALU, R
RUISI, G
GIUDICE, MTL
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 1981, 481 (10): : 218 - 224
[36] Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial
Akhtar, Muhammad Asim
Hadzhieva, Zoya
Ilyas, Kanwal
Ali, Muhammad Saad
Peukert, Wolfgang
Boccaccini, Aldo R.
PHARMACEUTICS, 2021, 13 (10)
[37] Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands
Silva, Francisco
Marques, Fernanda
Santos, I. C.
Paulo, Antonio
Rodrigues, Antonio Sebastiao
Rueff, Jose
Santos, Isabel
JOURNAL OF INORGANIC BIOCHEMISTRY, 2010, 104 (05) : 523 - 532
[38] Synthesis and crystal structure of unprecedented oxo/hydroxo-bridged polynuclear gallium(III) aqua complexes
Gerasko, OA
Mainicheva, EA
Naumov, DY
Kuratieva, NV
Sokolov, MN
Fedin, VP
INORGANIC CHEMISTRY, 2005, 44 (12) : 4133 - 4135
[39] AQUEOUS COMPLEXES OF GALLIUM(III)
HARRIS, WR
MARTELL, AE
INORGANIC CHEMISTRY, 1976, 15 (03) : 713 - 720
[40] Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes
Dell' Amico, Daniela Belli
Labella, Luca
Marchetti, Fabio
Samaritani, Simona
Alejandro Hernandez-Fuentes, Gustavo
Garcia-Argaez, Aida Nelly
Dalla Via, Lisa
POLYHEDRON, 2016, 119 : 396 - 402

← 1 2 3 4 5 →