Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes

被引：22

作者：

Zanias, Stergios ^{[2
]}

Papaefstathiou, Giannis S. ^{[3
]}

Raptopoulou, Catherine P. ^{[4
]}

Papazisis, Konstantinos T. ^{[5
]}

Vala, Vasiliki ^{[5
]}

Zambouli, Dimitra ^{[5
]}

Kortsaris, Alexandros H. ^{[5
]}

Kyriakidis, Dimitrios A. ^{[1
,6
]}

Zafiropoulos, Theodoros F. ^{[2
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece

[2] Univ Patras, Dept Chem, Patras 26504, Greece

[3] Natl & Kapodistrian Univ Athens, Dept Chem, Inorgan Chem Lab, Panepistimiopolis 15771, Zografou, Greece

[4] NCSR Demokritos, Inst Mat Sci, Aghia Paraskevi 15310, Greece

[5] Theagenion Krankenhauses, Thessaloniki 54007, Greece

[6] Natl Hellen Res Fdn, Athens 11635, Greece

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2010年 / 2010卷

关键词：

CRYSTAL-STRUCTURE; CELL-LINE; IN-VITRO; ANTITUMOR; CHEMISTRY; BINDING; LIGAND;

D O I：

10.1155/2010/168030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr3 or GaCl3 resulted in the mononuclear complexes [ GaBr3(btaH) 2] (1) and [ GaCl3(btd) 2] (2), respectively, while treatment of GaCl3 with L resulted in the anionic complex (LH)(2)[GaCl4] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

引用

页数：10

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