Expression of CD64 (FcγRI) in skin of patients with acute GVHD

被引：2
|
作者：
van Royen-Kerkhof, A. [1 ,2 ]
Walraven, V. [2 ]
Sanders, E. A. M. [2 ]
de Weger, R. [3 ]
van Wichen, D. F. [3 ]
de Koning, E. [3 ]
Thepen, T. [4 ]
van de Winkel, J. G. J. [1 ,5 ]
Leusen, J. H. W. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Immunotherapy Lab, Dept Immunol, NL-3584 EA Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Pediat Immunol, NL-3584 EA Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Dept Mol Pathol, NL-3584 EA Utrecht, Netherlands
[4] Fraunhofer IME, Dept Pharmaceut Prod Dev, Aachen, Germany
[5] Genmab, Utrecht, Netherlands
来源：
BONE MARROW TRANSPLANTATION | 2011年 / 46卷 / 12期
关键词：
graft-versus-host disease; IgG receptor; CD64; immunotherapy; macrophage; VERSUS-HOST-DISEASE; DENDRITIC CELLS; MACROPHAGES; RECEPTOR; TRANSPLANTATION; POLYMORPHISM;
D O I：
10.1038/bmt.2010.337
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
GVHD remains a major problem in allo-SCT. We explored the presence of APC in skin biopsies of GVHD patients, using the IgG receptor CD64 expression as a hallmark for activated APC. By immunohistochemistry we demonstrated CD64 to be upregulated on host APC in skin biopsies of patients with acute GVHD and, less prominently, in chronic GVHD. Double staining for CD32 polymorphism revealed CD64-positive cells to be mainly of host origin. The majority of CD64-positive cells coexpressed CD68, indicating a macrophage phenotype. Given its very restricted cellular distribution, CD64 may represent an excellent target for APC-directed therapies in GVHD. Bone Marrow Transplantation (2011) 46, 1566-1569; doi:10.1038/bmt.2010.337; published online 17 January 2011
引用
收藏
页码：1566 / 1569
页数：4
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