Expression of CD64 (FcγRI) in skin of patients with acute GVHD

被引：2
|
作者：
van Royen-Kerkhof, A. [1 ,2 ]
Walraven, V. [2 ]
Sanders, E. A. M. [2 ]
de Weger, R. [3 ]
van Wichen, D. F. [3 ]
de Koning, E. [3 ]
Thepen, T. [4 ]
van de Winkel, J. G. J. [1 ,5 ]
Leusen, J. H. W. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Immunotherapy Lab, Dept Immunol, NL-3584 EA Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Pediat Immunol, NL-3584 EA Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Dept Mol Pathol, NL-3584 EA Utrecht, Netherlands
[4] Fraunhofer IME, Dept Pharmaceut Prod Dev, Aachen, Germany
[5] Genmab, Utrecht, Netherlands
来源：
BONE MARROW TRANSPLANTATION | 2011年 / 46卷 / 12期
关键词：
graft-versus-host disease; IgG receptor; CD64; immunotherapy; macrophage; VERSUS-HOST-DISEASE; DENDRITIC CELLS; MACROPHAGES; RECEPTOR; TRANSPLANTATION; POLYMORPHISM;
D O I：
10.1038/bmt.2010.337
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
GVHD remains a major problem in allo-SCT. We explored the presence of APC in skin biopsies of GVHD patients, using the IgG receptor CD64 expression as a hallmark for activated APC. By immunohistochemistry we demonstrated CD64 to be upregulated on host APC in skin biopsies of patients with acute GVHD and, less prominently, in chronic GVHD. Double staining for CD32 polymorphism revealed CD64-positive cells to be mainly of host origin. The majority of CD64-positive cells coexpressed CD68, indicating a macrophage phenotype. Given its very restricted cellular distribution, CD64 may represent an excellent target for APC-directed therapies in GVHD. Bone Marrow Transplantation (2011) 46, 1566-1569; doi:10.1038/bmt.2010.337; published online 17 January 2011
引用
收藏
页码：1566 / 1569
页数：4
相关论文
共 50 条
  • [31] Subcutaneous administration of interleukin-2 triggers FcγRI (CD64) expression on human peripheral blood neutrophils (PMNs) of patients with solid and hematological malignancies.
    Sconocchia, G
    Campagnano, L
    Cococcetta, N
    Boffo, V
    Iorio, B
    Adorno, D
    Morino, L
    Amadori, S
    Casciani, CU
    BLOOD, 1999, 94 (10) : 44B - 44B
  • [32] CD64/FC-GAMMA-RI IS A GRANULO-MONOCYTIC LINEAGE MARKER ON CD34(+) HEMATOPOIETIC PROGENITOR CELLS
    OLWEUS, J
    LUNDJOHANSEN, F
    TERSTAPPEN, LWMM
    BLOOD, 1995, 85 (09) : 2402 - 2413
  • [33] Fc-γRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection
    Ioan-Facsinay, A
    de Kimpe, SJ
    Hellwig, SMM
    van Lent, PL
    Hofhuis, FMA
    van Ojik, HH
    Sedlik, C
    da Silveira, SA
    Gerber, J
    de Jong, YF
    Roozendaal, R
    Aarden, LA
    van den Berg, WB
    Saito, T
    Mosser, D
    Amigorena, S
    Izui, S
    van Ommen, GJB
    van Vugt, M
    van de Winkel, JGJ
    Verbeek, JS
    IMMUNITY, 2002, 16 (03) : 391 - 402
  • [34] Fcγ Receptor 1 (CD64), a Target Beyond Cancer
    Thepen, T.
    Huhn, M.
    Melmer, G.
    Tur, M. K.
    Barth, S.
    CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (23) : 2712 - 2718
  • [35] The novel applications of the quantitative analysis of neutrophil cell surface FcγRI (CD64) to the diagnosis of infectious and inflammatory diseases
    Nuutila, Jari
    CURRENT OPINION IN INFECTIOUS DISEASES, 2010, 23 (03) : 268 - 274
  • [36] CD64/FC-GAMMA-RI IS A SPECIFIC GRANULO-MONOCYTIC LINEAGE MARKER ON CD34+ HEMATOPOIETIC PROGENITOR CELLS
    OLWEUS, J
    LUNDJOHANSEN, F
    TERSTAPPEN, LWMM
    BLOOD, 1994, 84 (10) : A420 - A420
  • [37] CD64 EXPRESSION IN PATIENTS WITH CHRONIC PROSTATITIS AND ITS IMPLICATION IN DIAGNOSIS
    Cao, Jinghe
    Sun, Baogang
    Fan, Yingying
    Liu, Zhuang
    Zhang, Ning
    FARMACIA, 2018, 66 (02) : 262 - 266
  • [38] INCREASED EXPRESSION OF NEUTROPHIL AND MONOCYTE CD64 IN PATIENTS WITH ACTIVE TUBERCULOSIS
    Gatti, Arianna
    Righi, Sabrina
    Magnani, Carlo
    Agrappi, Carlo
    Radrizzani, Danilo
    Vigano', Paolo
    Clerici, Pierangelo
    Brando, Bruno
    CYTOMETRY PART B-CLINICAL CYTOMETRY, 2011, 80B (06) : 424 - 424
  • [39] Expression of CD64 on polymorphonuclear neutrophils in patients with familial Mediterranean fever
    Migita, K.
    Agematsu, K.
    Yamazaki, K.
    Suzuki, A.
    Yazaki, M.
    Jiuchi, Y.
    Miyashita, T.
    Izumi, Y.
    Koga, T.
    Kawakami, A.
    Eguchi, K.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2011, 164 (03): : 365 - 372
  • [40] Neutrophil CD64 expression in acute inflammatory arthritides and in systemic infections.
    Bakke, AC
    Allen, E
    Paiva, E
    Deodhar, A
    FASEB JOURNAL, 2000, 14 (06): : A1237 - A1237
12345