Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr

被引：7
|
作者：
Cai, Cancan [1 ,2 ]
Zhang, Yu [1 ]
Yang, Dongqiong [1 ,2 ]
Hao, Xiaojiang [1 ]
Li, Shunlin [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ci, Kunming, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 21期
基金：
中国国家自然科学基金;
关键词：
Wedelia chinensis; kauranetype diterpenoids; antibacterial activity; PROSTATE-CANCER; ASTERACEAE; EXTRACT; GROWTH;
D O I：
10.1080/14786419.2017.1317775
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new kaurane-type diterpenoids, 3 alpha-(angeloyloxy)-17-hydroxyent-kaur-15-en-19-oic acid (1) and 3 alpha-(tigloyloxy)-17-hydroxy-entkaur- 15-en-19-oic acid (2), along with 10 known compounds (3-12) were isolated from the whole plant of Wedelia chinensis (Osbeck.) Merr. Their structures were elucidated on the basis of extensive spectroscopic analyses (UV, IR, MS and NMR) and comparison with literature data. Compounds 3 and 4 showed moderate inhibitory activity against the Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 19.35 and 18.31 mu g/mL, respectively. [GRAPHICS] .
引用
收藏
页码：2531 / 2536
页数：6
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