Design and synthesis of novel chrysene-linked pyrrolo[2,1-c] [1,4]-benzodiazepine hybrids as potential DNA-binding agents

被引：36
|
作者：
Kamal, A [1 ]
Ramesh, G [1 ]
Ramulu, P [1 ]
Srinivas, O [1 ]
Rehana, T [1 ]
Sheelu, G [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(03)00743-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3451 / 3454
页数：4
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