Design and synthesis of novel chrysene-linked pyrrolo[2,1-c] [1,4]-benzodiazepine hybrids as potential DNA-binding agents

被引：36

作者：

Kamal, A ^{[1
]}

Ramesh, G ^{[1
]}

Ramulu, P ^{[1
]}

Srinivas, O ^{[1
]}

Rehana, T ^{[1
]}

Sheelu, G ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(03)00743-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3451 / 3454

页数：4

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